Study of Latinos (SOL) Ojos

拉丁裔研究 (SOL) 奥霍斯

• 批准号: 10232086
• 负责人: CHARLOTTE E JOSLIN
• 金额: $ 249.27万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10232086
• 关键词: Acculturation; Address; Admixture; Adult; African; African American; Age; Age related macular degeneration; American; Ancillary Study; Aphorisms; Asthma; Basic Science; Biological; Blindness; Blood Pressure; Body mass index; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caribbean region; Cataract; Censuses; Central American; Characteristics; Chicago; Chinese American; Chronic; Chronic Obstructive Airway Disease; Clinical Research; Cohort Studies; Communities; Community Surveys; Contact Lenses; Contracts; Cuban; Data; Data Collection; Dental caries; Detection; Diabetes Mellitus; Diabetic Retinopathy; Disabled Persons; Disease; Dominican; Elderly; Epidemiology; Ethnic group; Etiology; European; Eye; Eye diseases; Funding; Future; Genetic; Genotype; Glaucoma; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Hispanics; Impaired cognition; Inherited; Institutes; Kidney Diseases; Knowledge; Latino; Life Style; Lipids; Liver diseases; Los Angeles; Macular degeneration; Mexican; Mexican Americans; National Eye Institute; National Heart, Lung, and Blood Institute; Native Americans; Open-Angle Glaucoma; Ophthalmic examination and evaluation; Outcome; Participant; Pathway interactions; Periodontal Diseases; Phenotype; Physical activity; Population; Positioning Attribute; Prevalence; Probability; Protocols documentation; Puerto Rican; Questionnaires; Reporting; Research; Research Design; Research Support; Resources; Risk Factors; Sampling; Serum; Sleep Disorders; South American; Standardization; Stroke; Structure; Study of Latinos; Systemic disease; Time; United States National Institutes of Health; Vision; Visit; Visual impairment; Weight; aged; blind; burden of illness; cohort; design; diabetic; epidemiology study; genetic analysis; hearing impairment; inflammatory marker; innovation; lymphotoxin beta; novel; population based; prevent; prospective; racial and ethnic; recruit; social culture; sociodemographics

PROJECT SUMMARY/ABSTRACT This application proposes an ancillary eye study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a prospective, population-based, multicenter cohort, funded by the National Heart, Lung, and Blood Institute (NHLBI) and 6 other National Institutes of Health (NIH) Institutes, that is designed to 1) assess disease burden; and, 2) address cardiovascular disease (CVD), stroke, asthma, chronic obstructive pulmonary disease, sleep disorders, dental caries and periodontal disease, hearing impairment, diabetes, kidney and liver disease, and cognitive impairment. This landmark study, the largest ever conducted in Hispanics/Latinos, constitutes a national resource of extensive, high-quality phenotypic and genotypic data. Participants include those of Mexican, Cuban, Dominican, Puerto Rican, Central and South American, and Other origins. HSHC/SOL recruited 16,415 participants for Visit #1 (2008-2011); data collection for Visit #2 (2014-2017) concluded 12/17 (Chicago and Miami Field Centers: 82.3% participation rate); and, NHLBI contracted HCHS/SOL Visit #3 (2019-2022) funding to serve as a platform for ancillary studies. We will recruit and perfom a detailed eye exam on 2500 HCHS/SOL participants from Chicago and Miami aged ≥40 years to coincide with Visit #3. The HCHS/SOL Coordinating Center will provide direction in oversampling older adults to maximize disease detection efficiency, with sampling weights reflecting probabilities of selection to maintain accurate prevalence rates. Latinos of diverse backgrounds as in HCHS/SOL represent a rich sociocultural and genetically admixed group, inheriting a mixture of European, Native American, and African ancestry from populations previously isolated. As such, the HCHS/SOL Eye Study will represent the first highly admixed eye epidemiology cohort. This heterogeneity and intrinsic variability, essential in basic and clinical research, innovatively positions the HCHS/SOL Eye Study to assess important etiologic pathways amid prevalent risk factors and outcomes that cannot be assessed with homogenous cohorts. We propose to collect high-quality eye outcome data, identical to National Eye Institute (NEI)-funded population-based cohorts, which will allow the eye epidemiology community to, for the first time, assess novel hypotheses associated with systemic disease in a well-characterized, diverse cohort. The HCHS/SOL Eye Study is designed to 1) assess and compare the 2010 age-standardized prevalence of chronic eye disease across Hispanic/Latino groups using previously constructed HCHS/SOL “genetic analysis groups” (Mainland: Mexicans, Central and South Americans; and, Caribbean: Cubans, Dominicans, and Puerto Ricans); and, 2) assess whether prevalent disease is associated with novel CVD, biomedical, and sociocultural risk factors. Proposed research leverages NHLBI-funded epidemiologic research supported by 6 other NIH Institutes, and represents a significant opportunity for highly innovative and efficient epidemiologic eye research.

项目摘要/摘要 该申请提出了对拉美裔西班牙裔社区健康研究/研究的辅助眼睛研究 （HCHS/SOL）。 HCHS/SOL是一个前瞻性，基于人群的多中心队列，由国家心脏资助， 肺部和血液研究所（NHLBI）和其他6个国家卫生研究院（NIH）研究所旨在 1）评估伯恩疾病； 2）解决心血管疾病（CVD），中风，哮喘，慢性阻塞性 肺部疾病，睡眠障碍，龋齿和牙周疾病，听力障碍，糖尿病， 肾脏和肝病，以及认知障碍。这项具有里程碑意义的研究是有史以来最大的 西班牙裔/拉丁美洲人构成了全国性的资源，具有广泛的，高质量的表型和基因型数据。 参加者包括墨西哥，古巴，多米尼加，波多黎各，中美洲和南美的参与者，以及 其他起源。 HSHC/SOL招募了16,415名参与者参观＃1（2008-2011）；访问＃2的数据收集 （2014-2017）总结了12/17（芝加哥和迈阿密现场中心：参与率为82.3％）；而且，NHLBI 合同的HCHS/SOL访问＃3（2019-2022）作为辅助研究平台的资金。我们将招募 以及对来自芝加哥和迈阿密的2500 HCHS/SOL参与者的详细眼科检查，年龄≥40岁 与3号访问相吻合。 HCHS/SOL协调中心将提供过度采样老年人的方向 为了最大化疾病检测效率，取样重量反映了选择的可能性 准确的患病率。像HCHS/SOL中的潜水员背景的拉丁美洲人代表着丰富的社会文化和 遗传上的混合群体，从欧洲，美洲原住民和非洲血统的混合物中继承 以前隔离的人群。因此，HCHS/SOL眼睛研究将代表第一个高度混合的眼睛 流行病学队列。这种异质性和内在可变性，在基础和临床研究中必不可少， 创新地定位HCHS/SOL眼研究以评估普遍风险的重要病因学途径 不能用同质人群评估的因素和结果。我们建议收集高质量 引人注目的结果数据，与国家眼睛研究所（NEI）基于人群的同伙相同，这将允许 眼睛流行病学社区首次评估与全身性相关的新假设 疾病中的疾病良好，潜水队的队列。 HCHS/SOL眼研究设计为1）评估和 比较2010年在西班牙裔/拉丁美洲裔中慢性眼病的年龄标准化率 使用先前构建的HCHS/SOL“遗传分析组”（大陆：墨西哥人，中央和 南美人；还有加勒比海：古巴人，多米尼加人和波多黎各人）； 2）评估是否 普遍的疾病与新型CVD，生物医学和社会文化危险因素有关。建议的 研究利用NHLBI资助的流行病学研究由其他6个NIH机构支持，并代表 高度创新和有效的流行病学研究的重要机会。