Laser-Based Exhaled Breath Nitric Oxide Analyzer

基于激光的呼出气一氧化氮分析仪

• 批准号: 6647441
• 负责人: GREGORY J FETZER
• 金额: $ 42.56万
• 依托单位: ARETE ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647441
• 关键词: asthma; biomedical equipment development; breath tests; clinical research; diagnosis design /evaluation; human subject; lasers; nitric oxide; patient monitoring device; patient oriented research; pulmonary respiration; respiratory disorder diagnosis; semiconduction

DESCRIPTION (provided by applicant): In this Phase II program we propose continued development of a new nitric oxide (NO) sensor. The sensor is intended for use in assessment of airway inflammation with applications in asthma diagnosis and management as well as in other health care applications involving inflammation in the gastrointestinal tract and the urogenital organs. We use the relatively new Quantum Cascade (QC) distributed feedback semiconductor lasers and flexible hollow waveguides that serve as a light guide and a gas sample cell to produce a tunable Mid-InfraRed semiconductor Laser Absorption Spectrometer (MIRLAS). The QC lasers operate in the mid-infrared region of the electromagnetic spectrum where NO exhibits a strong band of absorption. We use wavelength modulation spectroscopy to provide measurements that are species specific to assure that measurements are relatively free of interference effects from other constituents of the sample stream. The small sample volumes presented by the hollow waveguide and a proprietary gas exchange assembly provide for rapid response to gas concentration changes. In Phase I, using MIRLAS, we demonstrated a 58.8 ppb NO detection limit with a 0 to 90% rise time of 0.48 s. These measurements are the first of their kind reported in the world. The feasibility of our approach has been clearly demonstrated. The markets for such a device are extensive. The instrument is compact and lightweight and could easily be deployed in physician's offices, health care clinics and emergency rooms. As an indicator of the commercial significance Arete Associates has formed a strategic alliance with Aerocrine AB, a commercial medical device company specializing in airway inflammation diagnosis. Plans for development and marketing are ongoing and evidenced by their participation in this program.

描述（由申请人提供）：在此第二阶段计划中，我们建议继续开发新型一氧化氮 (NO) 传感器。该传感器旨在用于评估气道炎症，应用于哮喘诊断和管理，以及涉及胃肠道和泌尿生殖器官炎症的其他医疗保健应用。我们使用相对较新的量子级联（QC）分布式反馈半导体激光器和柔性空心波导作为光导和气体样品池来生产可调谐中红外半导体激光吸收光谱仪（MIRLAS）。 QC 激光器在电磁波谱的中红外区域工作，其中 NO 表现出很强的吸收带。我们使用波长调制光谱来提供特定物种的测量，以确保测量相对不受样品流其他成分的干扰影响。中空波导和专有的气体交换组件提供的小样本体积可以对气体浓度变化做出快速响应。在第一阶段，我们使用 MIRLAS 证明了 58.8 ppb NO 检测限，0 至 90% 的上升时间为 0.48 秒。这些测量结果是世界上首次报道的此类测量结果。我们的方法的可行性已被清楚地证明。这种设备的市场非常广泛。该仪器结构紧凑、重量轻，可以轻松部署在医生办公室、医疗保健诊所和急诊室。作为商业意义的一个指标，Arete Associates 与 Aerocrine AB 结成了战略联盟，Aerocrine AB 是一家专门从事气道炎症诊断的商业医疗设备公司。开发和营销计划正在进行中，并通过他们参与该计划得到证明。