A Laser-Based Exhaled Breath Nitric Oxide Analyzer

基于激光的呼出气一氧化氮分析仪

• 批准号: 6401313
• 负责人: GREGORY J FETZER
• 金额: $ 8.68万
• 依托单位: ARETE ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2002-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401313
• 关键词: asthma; biomedical equipment development; breath tests; diagnosis design /evaluation; lasers; nitric oxide; pulmonary respiration; respiratory disorder diagnosis; semiconduction

We propose the development of an instrument to measure the concentration of nitric oxide(NO) in exhaled breath as an asthma diagnosis tool. The analyzer uses the combination of a proprietary hollow optical waveguide measurement cell, tunable semiconductor laser, and wavelength modulation spectroscopy to provide sensitive and reliable measurements of NO in air. The sensor will exhibit rapid response time (<1 s), low minimum detection limits (100's of parts per trillion for NO in air) and will be physically compact relative to other sensors with similar sensitivity. The compact, lightweight nature of the sensor coupled with its sensitivity provides a significant innovation in comparison to existing technologies. In Phase I, a benchtop measurement system will be constructed and tested. The system will be challenged with a variety of concentrations of NO in laboratory air. Phase II will consist of the development and optimization of a prototype instrument that will be used in research trials with human subjects. The gas sensor will be interfaced to a pneumatic sampling system that will allow exhaled breath samples to be tested. Once the system is functioning a small sample of human subjects will be tested in collaboration with Aerocrine AB, a commercial biomedical device company. PROPOSED COMMERCIAL APPLICATIONS: The proposed device would have applications in hospitals, emergency rooms, and doctors' offices and perhaps even in home use in monitoring of NO in exhaled breath as a tool for asthma diagnosis and control. Other applications are possible in the diagnosis of sick bowel syndrome, urinary tract infection and exhaled breath analysis for CO in cystic fibrosis patients. Finally the development of this technology has far reaching applications in indoor health and environmental monitoring.

我们提出了一种仪器的开发，以测量呼出呼吸中的一氧化氮（NO）作为哮喘诊断工具的浓度。该分析仪使用专有的空心光学波导测量单元，可调半导体激光器和波长调制光谱的组合，以提供空气中NO的敏感且可靠的测量。传感器将显示快速响应时间（<1 s），最小检测极限（空气中100亿零件的100零件），并且相对于其他具有相似灵敏度的传感器，它们在物理上是紧凑的。与现有技术相比，传感器的紧凑，轻巧的性质以及其灵敏度为其敏感性提供了重要的创新。在第一阶段，将构建和测试台式测量系统。该系统将受到实验室空气中各种NO浓度的挑战。第二阶段将包括将在人类受试者的研究试验中使用的原型仪器的开发和优化。气体传感器将连接到气动采样系统，该系统将允许测试呼出的呼吸样品。一旦该系统运行，将与商业生物医学设备公司Aerocrine AB合作测试一小部分人类受试者。拟议的商业应用：拟议的设备将在医院，急诊室和医生的办公室中提供应用程序，甚至可以在家庭使用中使用呼气呼吸中的No no no呼气，作为哮喘诊断和控制的工具。对于囊性纤维化患者的CO诊断，尿路感染和呼出的呼吸分析，其他应用是可能的。最后，这项技术的开发在室内健康和环境监测中已达到了众多应用。