Rodent Radio for Neurological Studies

用于神经学研究的啮齿动物无线电

• 批准号: 6656972
• 负责人: EDWARD J. RAPP
• 金额: $ 47.29万
• 依托单位: CLEVELAND MEDICAL DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656972
• 关键词: biomedical equipment development; electrocardiography; electroencephalography; electromyography; electrophysiology; ethology; laboratory mouse; laboratory rat; miniature biomedical equipment; monitoring device; neurophysiology; portable biomedical equipment; radiowave radiation; telemetry

DESCRIPTION (provided by applicant): The aim of this project is to develop a physiological wireless monitoring device that is small enough to be worn by a mouse or juvenile rat. This device will allow behavior to be observed and physiological parameters to be measured without tethering the rodent as is traditionally required. The Phase I of this program developed a small, two channel wireless physiological monitor transmitter that allows EEG, EKG, EMG and other physiological parameters of rats and other small animals to be measured by researchers. The Phase I developed a transmitter, which is small enough to be worn by a rat, and demonstrated the feasibility of such a device. It contains a data acquisition section, a digital section, and a programmable RF transmitter section. It is packaged in a silicone dip, which will protect the device from urine and other fluids as well as from electric shock. It has been tested on rats at John Hopkins Medical Institutions. In Phase II, the transmitter will be shrunk to allow it to be used for developing rats or mice environments. The transmitter will have sufficient range to allow the animals to freely move about their environment, which will allow for free maze studies, and even mazes that include navigating through water. Testing on the RatPaak will be continued at Johns Hopkins during the Phase II as well as testing on the newly developed MousePaak.

描述（由申请人提供）：该项目的目的是开发一种生理无线监测设备，该设备足够小，可供小鼠或幼年大鼠佩戴。该装置将允许观察行为并测量生理参数，而无需像传统要求那样束缚啮齿动物。 该项目一期开发了一款小型两通道无线生理监测发射器，研究人员可以测量大鼠和其他小动物的脑电图、心电图、肌电图和其他生理参数。第一阶段开发了一种小到可以被老鼠佩戴的发射器，并证明了这种设备的可行性。它包含数据采集部分、数字部分和可编程射频发射器部分。它采用硅胶浸料包装，可保护设备免受尿液和其他液体的影响以及电击。它已在约翰·霍普金斯医疗机构的老鼠身上进行了测试。 在第二阶段，发射器将被缩小，以使其能够用于培养大鼠或小鼠环境。发射器将有足够的范围让动物在其环境中自由移动，这将允许自由迷宫研究，甚至包括在水中导航的迷宫。在第二阶段，约翰·霍普金斯大学将继续对 RatPaak 进行测试，并对新开发的 MousePaak 进行测试。