Untethered Mouse EEG Radio for Sleep

用于睡眠的无线鼠标脑电图无线电

• 批准号: 7154250
• 负责人: EDWARD J. RAPP
• 金额: $ 19.98万
• 依托单位: CLEVELAND MEDICAL DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7154250
• 关键词: biomedical automation; biomedical equipment development; computer data analysis; computer program /software; computer system design /evaluation; electrodes; electroencephalography; electromyography; electrophysiology; ethology; laboratory mouse; laboratory rat; miniature biomedical equipment; polysomnography; psychopharmacology; psychophysiology; sleep; surgery

DESCRIPTION (provided by applicant): This proposed project will develop a small wireless device that is capable of monitoring brain activity (EEG) in mice as well as other physiological signals, such as EMG and ECG. Presently, brain activity is monitored using a cable tethered to the mouse and to the top of the cage, which does not permit natural activity nor any tunnels or most other typical housing accessories. Although new wireless devices have been developed, their sensitivity is not adequate for accurate brain activity monitoring. CleveMed has developed a small wireless monitoring device, the MousePaak(tm), and this proposed project will make that MousePaak even smaller, hence even less obtrusive to the mouse to permit even more natural activity, and add new automated software to provide sleep staging information. This new device and software will be invaluable in testing both the new pharmaceutical breakthroughs for the estimated 40 million individuals in the United States that experience chronic or intermittent sleep-related problems and disorders, and for testing the effect other pharmaceutical breakthroughs might have on normal sleep. The proposed project will develop a wireless solution for monitoring brain and muscle activity of mice both during normal activities and while sleeping. In particular, this project will also develop automated software for sleep staging using this monitor. This proposed device will be an essential tool for testing pharmaceutical breakthroughs and how they affect brain function and especially sleep patterns.

描述（由申请人提供）：该拟议项目将开发一种小型无线设备，能够监测小鼠的大脑活动（EEG）以及其他生理信号，例如肌电图和心电图。目前，使用拴在小鼠和笼子顶部的电缆来监测大脑活动，这不允许自然活动，也不允许任何隧道或大多数其他典型的外壳配件。尽管已经开发出新的无线设备，但它们的灵敏度不足以准确监测大脑活动。 CleveMed 开发了一种小型无线监测设备 MousePaak(tm)，该拟议项目将使 MousePaak 变得更小，因此对鼠标的干扰更小，从而允许更自然的活动，并添加新的自动化软件来提供睡眠分期信息。这种新设备和软件对于测试新的药物突破以及测试其他药物突破可能对正常睡眠产生的影响具有不可估量的价值，美国估计有 4000 万患有慢性或间歇性睡眠相关问题和障碍的人。拟议的项目将开发一种无线解决方案，用于监测小鼠在正常活动和睡眠期间的大脑和肌肉活动。特别是，该项目还将开发使用该监视器进行睡眠分期的自动化软件。该设备将成为测试药物突破及其如何影响大脑功能（尤其是睡眠模式）的重要工具。