ACQUISTION OF A 300 MHZ NMR SPECTROMETER

购买 300 MHZ 核磁共振波谱仪

• 批准号: 6053083
• 负责人: GLENN DOWNES PRESTWICH
• 金额: $ 21.5万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2001-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053083
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

This proposal requests funds to acquire a Varian Mercury 300 MHz high- resolution NMR spectrometer. This instrument will be housed in The Department of Medicinal Chemistry at The University of Utah (UU) and will serve nine primary biomedical research groups in two departments within the College of Pharmacy (Medicinal Chemistry and Pharmaceutics and Pharmaceutical Chemistry). These research groups comprise over 45 graduate students and postdoctoral associates who rely on daily access to routine NMR for their work in organic synthesis, polymer characterization, and small molecule natural products structure determination. This instrument will replace a 15-year old 200 MHz instrument, and will be the only instrument available for routine small molecule analysis to serve the needs of researchers located within the Health Sciences Center at UU. Minor users from the School of Medicine include the Departments of Radiology, Oncological Sciences, Biochemistry, Physiology, and Human Genetics. The new 300 MHz NMR would be managed by faculty and staff in Medicinal Chemistry and chaired by the Principal Investigator. The NMR Facility Director, Professor Darrell R. Davis, will oversee the instrument purchase and installation, and will coordinate the instrument use, maintenance, and user training.

该提案请求资金购买 Varian Mercury 300 MHz 高分辨率 NMR 波谱仪。该仪器将安装在犹他大学 (UU) 药物化学系，为药学院两个系（药物化学和药剂学以及药物化学）的 9 个主要生物医学研究小组提供服务。这些研究小组由超过 45 名研究生和博士后组成，他们每天依靠常规 NMR 进行有机合成、聚合物表征和小分子天然产物结构测定的工作。该仪器将取代已有 15 年历史的 200 MHz 仪器，并将成为唯一可用于常规小分子分析的仪器，以满足 UU 健康科学中心研究人员的需求。医学院的小用户包括放射学系、肿瘤科学系、生物化学系、生理学系和人类遗传学系。新的 300 MHz NMR 将由药物化学系的教职员工管理，并由首席研究员主持。 NMR 设施主任 Darrell R. Davis 教授将监督仪器的购买和安装，并协调仪器的使用、维护和用户培训。

项目成果

Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.

来自 Petrosia 海绵的细胞毒性异喹啉醌。

• 发表时间: 2004-02
• 作者: Sandoval, Imelda T;Davis, Rohan A;Bugni, Tim S;Concepcion, Gisela P;Harper, Mary Kay;Ireland, Chris M
• 通讯作者: Ireland, Chris M

Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp.

来自菲律宾海洋海绵 Smenospongia sp 的细胞毒性溴吲哚衍生物和萜烯。

• 发表时间: 2002-09
• 作者: Tasdemir, Deniz;Bugni, Timothy S;Mangalindan, Gina C;Concepción, Gisela P;Harper, Mary Kay;Ireland, Chris M
• 通讯作者: Ireland, Chris M

Making the most of Papua New Guinea's biodiversity: Establishment of an integrated set of programs that link botanical survey with pharmacological assessment in "The Land of the Unexpected"

充分利用巴布亚新几内亚的生物多样性：建立一套综合计划，将植物调查与“意外之地”的药理学评估联系起来

• 发表时间: 2009-08-01
• 影响因子: 3.8
• 作者: Barrows LR;Matainaho TK;Ireland CM;Miller S;Carter GT;Bugni T;Rai P;Gideon O;Manoka B;Piskaut P;Banka R;Kiapranis R;Noro JN;Pond CD;Andjelic CD;Koch M;Harper MK;Powan E;Pole AR;Jensen JB
• 通讯作者: Jensen JB