CORE--MOLECULAR PHARMACOLOGY

核心--分子药理学

• 批准号: 6189645
• 负责人: GLENN DOWNES PRESTWICH
• 金额: --
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-05 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6189645
• 关键词: biomedical facility; chemical synthesis; drug design /synthesis /production; pharmacology

The Molecular Pharmacology Program (MPP) links chemical synthesis an drug discovery with the biochemistry, structural biology, cell biology, and whole organism pharmacology of potential new drug candidates. Our membership includes faculty from the College of Science, College of Pharmacy, School of Medicine, and College of Engineering in order to provide the translational knowledge that can lead from drug discovery to drug development. Faculty expertise includes the areas of (i) synthesis and analysis of organic molecules, phosphoinositides, and nucleic acids, (ii) isolation of new anti- cancer leaders from natural sources, molecules, phosphoinositides, and nucleic acids, (ii) isolation of new anti- cancer leads from natural sources, (iii) protein engineering, folding, modification, and purification, (iv) photoaffinity labeling and active site mapping of proteins, (v) structural studies of proteins, nucleic acids and the small molecule complex using crystallography and NMR, (vi) polymer synthesis and modification of anti-cancer drugs of targeted delivery, (vii) studies of dosage forms, distribution, and mechanisms of toxicity and metabolism of anti-cancer drugs, (viii) mechanisms of radio-protection and sensitization, (ix) computational studies of complex systems, (x) receptor- mediated signal transduction and vesicular trafficking, and (xi) new methodologies for biomolecular interaction analysis and functional genomic screens.

分子药理学计划 (MPP) 将化学合成、药物发现与潜在新药候选物的生物化学、结构生物学、细胞生物学和整个有机体药理学联系起来。我们的成员包括来自理学院、药学院、医学院和工程学院的教师，以提供从药物发现到药物开发的转化知识。教师的专业知识包括以下领域：(i) 有机分子、磷酸肌醇和核酸的合成和分析，(ii) 从天然来源、分子、磷酸肌醇和核酸中分离新的抗癌先导化合物，(ii) 分离新的抗癌药物。天然来源的抗癌线索，(iii) 蛋白质工程、折叠、修饰和纯化，(iv) 蛋白质的光亲和标记和活性位点图谱，(v) 使用晶体学对蛋白质、核酸和小分子复合物进行结构研究和核磁共振，（vi）靶向递送抗癌药物的聚合物合成与修饰，（vii）抗癌药物的剂型、分布、毒性和代谢机制研究，（viii）放射防护和致敏机制，（ix）复杂系统的计算研究，（x）受体介导的信号转导和囊泡运输，以及（xi）生物分子相互作用分析和功能基因组筛选的新方法。