HIGH RESOLUTION (>2 0 E) CRYSTAL STRUCTURE OF CATALYTIC ANTIBODIES

催化抗体的高分辨率 (>2 0 E) 晶体结构

• 批准号: 6586660
• 负责人: RAYMOND C STEVENS
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586660
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; immunology; inflammation; radiography; structural biology

Structural studies of catalytic antibodies in my laboratory focuses on six systems (i) Antibody-catalyzed ester hydrolysis, (ii) An antibody ferrochelastase, (iii) Antibody-catalyzed aminoacylation reaction, (iv) An antibody-catalyzed regio- and stereoselective ketone reduction. To date, the field of catalytic antibodies has suffered from not having high resolution crystal structures to aid in the hapten/transition state ligand design. Without improved hapten design, the field will have a difficult time in improving the catalytic rates of the abzymes and in achieving the catalytic rates that are comparable to enzymes. Thus it is critical to obtain the highest resolution data possible to carefully understand how the catalytic antibodies function.

我实验室催化抗体的结构研究 重点关注六个系统（i）抗体催化的酯水解，（ii） 抗体亚铁螯合酶，(iii) 抗体催化的氨酰化 反应，(iv) 抗体催化的区域选择性和立体选择性酮 减少。 迄今为止，催化抗体领域已遭受重创 由于没有高分辨率晶体结构来帮助 半抗原/过渡态配体设计。 没有改进的半抗原 设计，该领域在改进 抗体酶的催化速率以及实现催化速率的过程 与酶相当。 因此，获得 尽可能高分辨率的数据，以仔细了解如何 催化抗体功能。