STRUCTURAL CHARACTERIZATION OF ORGANOCUPRATE COMPLEXES IN SOLUTION

溶液中有机铜配合物的结构表征

• 批准号: 6658672
• 负责人: James E. Penner-Hahn
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6658672
• 关键词: biological products; biomaterials; biomedical resource; spectrometry; structural biology; technology /technique

Organocuprate complexes have been a cornerstone of synthetic organic chemistry for more than two decades, and provide a highly efficient means of coupling and derivatizing organic molecules. However, little is known of the structure or mechanism of this important class of compounds. We propose to use static XAFS, time resolved XAFS and WAXS will be used to determine the solution speciation of selected, well characterized organocuprate complexes. The ultimate goal of this work is to characterize the molecular mechanism of organocuprate addition reactions so as to permit the rational design of improved organocuprate reagents, which are very relevant to a wide range of synthetic procedures used for biomolecule and drug synthesis.

Organocuprate复合物已成为合成的基石 有机化学已有二十多年了，并提供了高度 有效耦合和衍生有机分子的方法。 但是，对此的结构或机制知之甚少 重要的化合物类。 我们建议使用静态XAF，时间 已解决的XAF和蜡将用于确定解决方案 选定的，特征良好的有机酸盐配合物的形态。 这项工作的最终目标是表征分子 有组织添加反应的机制，以便允许 改进的Organocuprate试剂的合理设计，非常 与用于生物分子的多种合成程序有关 和药物合成。