XAS STRUCTURAL CHARACTERIZATION OF NO ADDUCTS OF HEMES

无血红素加合物的 XAS 结构表征

• 批准号: 6586708
• 负责人: PETER A LAY
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586708
• 关键词: biological products; biomaterials; biomedical resource; proteins; spectrometry; structural biology; technology /technique

Nitric oxide (NO) has been found to have an increasing number of biological roles including being a neurotransmitter. In a variety of these functions, it is known that NO is bound to heme proteins, but no detailed structural information is available on the nature of such binding. This project is aimed at using XAS data to understand the geometric and electronic structures of NO adducts of heme proteins. This structural information will also be used to gain a better understanding of how binding of NO activates the release of the NO-heme group from the heme protein.

一氧化氮（NO）的数量越来越多 生物学作用，包括是神经递质。 多种多样 这些功能，众所周知，不注是血红素蛋白，但没有 有关此类性质的详细结构信息 结合。 该项目旨在使用XAS数据来了解 无血红素蛋白加合物的几何和电子结构。 这些结构信息也将用于获得更好的 了解无约束力如何激活释放 来自血红素蛋白的无血红素组。