FAMILIAL FACTORS IN BARRETT'S ESOPHAGUS

巴雷特食管的家族因素

• 批准号: 6634749
• 负责人: AMITABH CHAK
• 金额: $ 13.24万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634749
• 关键词: Barretts esophagus; adenocarcinoma; endoscopy; family genetics; genetic susceptibility; human subject; longitudinal human study; patient oriented research

DESCRIPTION (provided by applicant) Advances in basic sciences often translate into an increased understanding of disease processes. Similarly, advances in endoscopic engineering also produce new technology with novel applications in clinical gastroenterology. I believe that patient-oriented researchers in gastrointestinal diseases and gastrointestinal endoscopy must translate advances in basic sciences and engineering technology to improved methods for patient care. Using my previous experience in basic research and training in advanced endoscopy, I have initiated and successfully implemented investigations that address this goal. My research objectives have been furthered by the opportunity to mentor several advanced gastroenterology fellows in the performance of specialized endoscopic procedures and patient-oriented research projects. These trainees are now productive clinical investigators in the field of gastrointestinal endoscopy. Protected time provided by this award will permit me to develop a meaningful research program that focuses on applying new endoscopic techniques and advances in human genetics to the evaluation of Barrett's esophagus and esophageal adenocarcinoma. The award will also further my education in two areas in which it is slightly deficient, viz., biostatistics and human genetics. Educational courses in these subjects and collaborations with experts in these fields will strengthen the development of my research program. Lastly, the award will allow me to teach advanced endoscopy to new trainees and mentor them in the development of their own research projects within my program. Esophageal adenocarcinoma is associated with a very poor prognosis. More effective screening, surveillance, and treatment strategies are required. The aim of the current proposal is to identify familial factors involved in the development of Barrett's esophagus and esophageal adenocarcinoma. The ultimate goal of this research program is to help identify the heritable genetic mutation(s) that determine susceptibility to Barrett's esophagus in order to improve screening and surveillance strategies for this disease.

描述（由申请人提供） 基础科学的进步通常会转化为对以下领域的理解的加深： 疾病过程。同样，内窥镜工程的进步也产生了 新技术在临床胃肠病学中的新应用。我相信 以患者为中心的胃肠道疾病研究人员和 胃肠内窥镜检查必须转化基础科学和技术的进步 工程技术来改进患者护理方法。使用我以前的 我在高级内窥镜基础研究和培训方面拥有丰富的经验 发起并成功实施了旨在实现这一目标的调查。 我的研究目标因指导几位专家的机会而得到进一步推进 高级胃肠病学研究员，擅长专业内窥镜检查 程序和以患者为导向的研究项目。这些实习生现在 胃肠内窥镜领域富有成效的临床研究人员。 该奖项提供的受保护时间将使我能够发展有意义的 研究计划，重点是应用新的内窥镜技术和 人类遗传学的进展对巴雷特食管的评估和 食管腺癌。该奖项还将进一步促进我在两个方面的教育 稍有不足​​的领域，即生物统计学和人类学 遗传学。这些科目的教育课程以及与专家的合作 在这些领域将加强我的研究计划的发展。最后， 该奖项将使我能够向新学员和导师教授高级内窥镜检查 他们在我的项目中开发自己的研究项目。 食管腺癌的预后非常差。更多的 需要有效的筛查、监测和治疗策略。这 当前提案的目的是确定涉及家庭因素 巴雷特食管和食管腺癌的发展。终极 该研究计划的目标是帮助识别可遗传的基因 决定对巴雷特食管易感性的突变，以便 改进该疾病的筛查和监测策略。