Pilot and Feasibility Program

试点和可行性计划

• 批准号: 10555249
• 负责人: AMITABH CHAK
• 金额: $ 17.59万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555249
• 关键词: Advisory Committees; Applications Grants; Area; Award; Categories; Clinic; Colitis; Collaborations; Crohn' s disease; Development; Digestive System Disorders; Eligibility Determination; Fostering; Foundations; Funding; Goals; Grant; Inflammation; Institution; Investigation; Investments; K-Series Research Career Programs; Liver diseases; Metabolism; Midwestern United States; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Peer Review; Peer Review Grants; Privatization; Process; Progress Reports; Qualifying; Research; Research Institute; Research Personnel; Resources; Review Committee; Science; Series; Study Section; Talents; Translating; Trust; United States National Institutes of Health; Universities; Update; Work; career development; cost; feasibility research; innovation; interest; member; minority investigator; programs; research study; skills; success; symposium; tumorigenesis

PILOT AND FEASIBILITY PROGRAM PROJECT SUMMARY The Cleveland DDRCC Pilot and Feasibility (P and F) Program is one of the fundamental pillars for the intellectual vitality and success of our Center. The Program directly supports the Center’s stated mission to foster innovation in the area of digestive disease-related research through the support of collaborative research, collaboration, and career development. The overall goal of the P and F program is to grow the number of investigators successfully performing research in the thematic areas of Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism at Case Western Reserve University (CWRU) Center and the Cleveland Clinic Foundation’s Lerner Research Institute (CCF LRI) by providing resources to develop new pilot and/or feasibility research studies that will lead to competitive peer-reviewed grant applications. The program, directed by Dr. Amitabh Chak, has a focus using P and F awards to support the development of independent research programs for junior investigators with an interest in digestive diseases research. The program also seeks to attract talented, established investigators in other fields to apply their research skills and expertise to digestive disease-related investigations. A call for applications is held each spring, and the program generally receives 20-30 proposals per year. The P and F Scientific Review Committee oversees peer-review of all qualifying applications, including both an internal review process and external review by members of the Cleveland DDRCC External Advisory Committee. The Center funds up to four $25,000 awards per year with NIDDK funding, as well as up to an additional two awards per year supported by institutional commitments. Awards are for one year, but recipients can apply for a second year of funding when needed. The P and F Program annually tracks the outcomes of all current and prior P and F Award recipients, and provides regular Progress Report updates to the NIDDK. We are particularly proud of the high level of success seen with our P and F Program during the previous funding cycle, with seven of our 15 P and F Awardees from 2015-2018 going on obtain peer-reviewed NIH or foundation grants based on work generated through their P and F project (including four K awards, one R01, one R21 for minority investigators, one P20 sub-project PI, two Crohn’s and Colitis Foundation Senior Research Awards, and one Helmsley Trust Award). P and F awardees have also been active in contributing to the enrichment programs of the Cleveland DDRCC, including founding the Young Investigators Network and its highly popular “Mock Study Section”, presenting their P and F projects at the annual Midwest DDRCC Alliance Research Symposium (hosted by the Cleveland DDRCC Mar 5-6, 2018), and organizing and participating in the Young Investigators Symposium included within the biannual two-day Cleveland IDEAS Symposium.

试点和可行性计划项目摘要 克利夫兰 DDRCC 试点和可行性（P 和 F）计划是该计划的基本支柱之一 我们中心的智力活力和成功直接支持了中心的既定使命。 通过合作的支持，促进消化系统疾病相关研究领域的创新 P 和 F 计划的总体目标是发展研究、协作和职业发展。 在消化专题领域成功开展研究的研究人员数量 凯斯西储大学 (CWRU) 的炎症/肿瘤发生和肝病/代谢 中心和克利夫兰诊所基金会勒纳研究所 (CCF LRI) 提供资源 开展新的试点和/或可行性研究，从而获得有竞争力的同行评审拨款 该计划由 Amitabh Chak 博士指导，重点利用 P 和 F 奖项来支持 为对消化系统疾病感兴趣的初级研究人员制定独立研究计划 该计划还寻求吸引其他领域有才华的知名研究人员应用他们的研究成果。 消化系统疾病相关研究的研究技能和专业知识每年都会进行申请征集。 春季，该计划通常每年收到 20-30 份 P and F 科学评论提案。 委员会监督所有合格申请的同行评审，包括内部评审流程和 克利夫兰 DDRCC 外部咨询委员会成员进行的外部审查 该中心资助最多。 每年由 NIDDK 资助提供四个 25,000 美元的奖项，以及每年最多另外两个奖项 由机构承诺支持的奖项为期一年，但获奖者可以申请第二年的资助。 P 和 F 计划每年跟踪所有当前和之前的 P 和 F 的结果。 获奖者，并向 NIDDK 定期提供进度报告更新，我们对此感到特别自豪。 我们的 P 和 F 计划在上一个融资周期中取得了高度成功，我们的 7 个项目 2015 年至 2018 年，15 名 P 和 F 获奖者根据工作继续获得同行评审的 NIH 或基金会资助 通过他们的 P 和 F 项目产生（包括 4 个 K 奖、1 个 R01 奖、1 个针对少数族裔研究人员的 R21 奖、1 个 P20子项目PI，两项克罗恩病和结肠炎基金会高级研究奖，一项赫尔姆斯利信托奖）。 P 和 F 获奖者还积极为克利夫兰 DDRCC 的丰富项目做出贡献， 包括成立青年调查员网络及其广受欢迎的“模拟研究部分”，展示他们的 年度中西部 DDRCC 联盟研究研讨会上的 P 和 F 项目（由克利夫兰 DDRCC 主办） 2018年3月5-6日），并组织和参加青年研究者研讨会 每年两次、为期两天的克利夫兰 IDEAS 研讨会。