GENETIC DETERMINANTS OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA

巴雷特食管和食管腺癌的遗传决定因素

基本信息

批准号：
9325717
负责人：
AMITABH CHAK
金额：
$ 46.3万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9325717
关键词：
Aberrant DNA Methylation Ablation Accounting Adult Affect Barrett Esophagus Basic Science Biological Biological Markers Center for Translational Science Activities Cessation of life Characteristics Chemoprevention Chronic Clinical Clinical Investigator Collaborations DNA Data Detection Development Diagnosis Disease Distant Early Detection Research Network Endoscopy Epidemiologist Epigenetic Process Epithelium Esophageal Adenocarcinoma Family member Fostering Foundations Gastroesophageal reflux disease Genetic Genetic Determinism Genetic Predisposition to Disease Genetic screening method Genomic DNA Genomics Goals Human In Situ Incidence Institution Instruction Knowledge Laboratories Laboratory Scientists Lead Malignant Neoplasms Methods MicroRNAs Modeling Molecular Molecular Genetics Morbidity - disease rate Mucous Membrane Obesity Outcome Patients Physiological Physiology Pilot Projects Productivity Public Health Publications Recording of previous events Research Research Personnel Research Project Grants Risk Schedule Serological Serum Susceptibility Gene Symptoms Techniques Testing Therapeutic Tissues Translating Translational Research base cancer diagnosis cohort deep sequencing exome sequencing family genetics genetic pedigree improved improved outcome male meetings molecular marker mortality outcome forecast predicting response prevent programs screening symposium transcriptome

Aberrant DNA Methylation Ablation Accounting Adult Affect Barrett Esophagus Basic Science Biological Biological Markers Center for Translational Science Activities Cessation of life Characteristics Chemoprevention Chronic Clinical Clinical Investigator Collaborations DNA Data Detection Development Diagnosis Disease Distant Early Detection Research Network Endoscopy Epidemiologist Epigenetic Process Epithelium Esophageal Adenocarcinoma Family member Fostering Foundations Gastroesophageal reflux disease Genetic Genetic Determinism Genetic Predisposition to Disease Genetic screening method Genomic DNA Genomics Goals Human In Situ Incidence Institution Instruction Knowledge Laboratories Laboratory Scientists Lead Malignant Neoplasms Methods MicroRNAs Modeling Molecular Molecular Genetics Morbidity - disease rate Mucous Membrane Obesity Outcome Patients Physiological Physiology Pilot Projects Productivity Public Health Publications Recording of previous events Research Research Personnel Research Project Grants Risk Schedule Serological Serum Susceptibility Gene Symptoms Techniques Testing Therapeutic Tissues Translating Translational Research base cancer diagnosis cohort deep sequencing exome sequencing family genetics genetic pedigree improved improved outcome male meetings molecular marker mortality outcome forecast predicting response prevent programs screening symposium transcriptome

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项目摘要

DESCRIPTION (provided by applicant): The overall objectives of this BETRNet Translational Research Center (TRC-F) are: 1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) 2) to increase the biological understanding of key observations made by our clinical researchers (familial aggregation of BE and EAC, restitution of squamous mucosa after ablation); 3) to translate knowledge derived from genetic and physiologic research to solving clinical dilemmas in detection, prognosis, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5) to evaluate research and transdisciplinary programs and to continuously Improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this TRCF proposal is 1) to focus research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; 2) to explore the physiologic, transcriptional, and epigenetic factors that lead to durable ablation of BE; and 3) to translate discoveries into applications that improve familial screening, effective detection, molecular prognostication, and durable ablation of BE.

描述（由申请人提供）：本订单转化研究中心（TRC-F）的总体目标是：1）在巴雷特的食管（BE）和食管食管腺癌（EAC）2中进行严格的，综合的跨学科人类研究谱，以增加对我们的临床群体的生物学统一的生物学理解，以增加对临床群体的生物学理解（家庭群体的生物学理解）（又是家族性的综合研究，消融后的粘膜）； 3）将源自遗传和生理研究得出的知识转化为解决临床困境，以防止EAC和改善EAC的结果； 4）培养跨学科和翻译研究文化的结果； 5）评估研究和跨学科计划，并不断提高研究，生产力和增强翻译实施。这些目标建立并协同为现有的多机构合作网络以及我们机构提供的大量临床，基础科学和翻译专业知识，重点是改善BE和EAC患者的成果。该TRCF提案的总体组织框架是1）将研究集中在理解影响BE和EAC发展的遗传易感性，基因组和表观遗传变化上； 2）探索导致BE持久消融的生理，转录和表观遗传因素； 3）将发现转化为改善家族性筛查，有效检测，分子预后和耐用BE的应用。