Core--Mouse transplantation

核心--小鼠移植

• 批准号: 6667404
• 负责人: SAUL Joseph SHARKIS
• 金额: $ 22.86万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667404
• 关键词: animal breeding; animal colony; biomedical facility; genetic screening; genetically modified animals; genotype; hematopoietic stem cells; hematopoietic tissue transplantation; laboratory mouse; stem cell transplantation; transplantation resource /registry /referral center

Core B is designed to provide centralized, specialized animal care for several strains of mice to include breeding colonies and purchased animals. Breeding of immuno-deficient and transgenic mice is required for our studies, as many of these strains are not commercially available, either in the quantities needed for our studies or at all. The large number of mice to be transplanted and monitored for engraftment represents the other major function of this core. In addition Core B will provide genotyping for transgenic mice bred under the auspices of this centralized core. We believe providing the expertise centrally for these service is efficient both scientifically and financially, and more important, makes is possible for all Projects to make rapid and effective use of several sophisticated mouse transplantation models.

Core B旨在为几种小鼠菌株提供集中的专门动物护理，包括繁殖菌落和购买的动物。我们的研究需要进行免疫缺陷和转基因小鼠的繁殖，因为这些菌株中的许多菌株都无法获得我们的研究数量，或者根本无法获得。要移植和监测植入的大量小鼠代表了该核心的另一个主要功能。另外，核心B将提供基因分型，用于在该集中核心的主持下繁殖的转基因小鼠。我们认为，在科学和财务上为这些服务提供专业知识既有效又有效，并且更重要的是，所有项目都可以快速和有效利用几种复杂的鼠标移植模型。