Improved Polymeric Restoratives Through Molecular Design

通过分子设计改进聚合物修复剂

• 批准号: 6523828
• 负责人: J DAVID EICK
• 金额: $ 110.46万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6523828
• 关键词: biomaterial development /preparation; biomaterial evaluation; composite resins; dental materials

PROGRAM PROJECT DESCRIPTION (provided by applicant): Previous research has produced an oxirane/polyol dental composite system that will be available for clinical testing by 03/02. The overall goal of this project is to apply an integrated approach involving innovative computer modeling and organic synthesis, novel biocompatibility evaluation, comprehensive materials characterization, and mechanistic development of improved dental composites. Our intent is "to improve the low stress/low shrinkage adhesive oxiranel/polyol composite system so that a restorative material will be produced that will be significantly better than methyacrylate based composite systems and be a suitable replacement for dental amalgam." The specific aims for the overall project are: 1) to focus our research efforts on understanding the underlining scientific principles governing the behavior of oxirane/polyol based composite systems; 2) through two cores to provide administrative, statistical, and budgetary support for the investigators, consultants, and program directors and to provide biocompatibility testing for the new materials; 3) through four R01 subprojects to employ computer modeling to develop low stress/low shrinkage resin matrix materials and adhesives, to study genetic and biomimetics responses of the new materials, and to improve to composite system; and 4) to continue to provide a stimulating research environment for the scientists and graduate students involved in this program. The improvement of advanced dental composites systems is greatly promoted when multi-disciplinary teams of scientists come together with their talent, laboratory resources, and equipment. Indeed, the purpose of this grant is to provide the synergistic focus for the team of scientists to improve the low stress/low shrinkage adhesive oxirane/polyol based composite system and to understand more fully the underlining scientific principals governing the behavior of theses materials. The cooperative efforts among the University of Missouri at Kansas City researchers, investigators at the Midwest Research Institute in Kansas City and researchers at the 3M Company has been most productive and have established the necessary cadre of scientists who can accomplish this overall objective. If we are successful, we will gain a deeper understanding of the behavior of low stress/low shrinkage oxirane/polyol based composite systems. Also, dental care for the general public will be substantially improved and a suitable replacement for dental amalgam will be available.

计划项目描述（由申请人提供）：先前的研究 已生产出环氧乙烷/多元醇牙科复合材料系统，即将上市 03/02 之前进行临床测试。该项目的总体目标是应用 涉及创新计算机建模和有机的综合方法 合成、新型生物相容性评价、综合材料 改进牙科复合材料的表征和机械开发。 我们的目的是“改进低应力/低收缩粘合剂环氧乙烷/多元醇 复合系统，以便生产出一种修复材料 明显优于基于甲基丙烯酸酯的复合系统，并且是 牙科汞合金的合适替代品。”整体的具体目标 项目是：1）将我们的研究工作集中在理解下面的内容上 控制环氧乙烷/多元醇基复合材料行为的科学原理 系统； 2）通过两个核心提供管理、统计和 为研究人员、顾问和项目主管提供预算支持 为新材料提供生物相容性测试； 3）通过四个R01 采用计算机建模来开发低应力/低收缩的子项目 树脂基质材料和粘合剂，用于研究遗传和仿生学 新材料的响应，以及复合体系的改进；和 4) 到 继续为科学家提供激励性的研究环境 参与该计划的研究生。先进牙科的改进 当多学科团队 科学家们汇集了他们的才华、实验室资源和 设备。事实上，这笔赠款的目的是提供协同作用 科学家团队专注于改善低应力/低收缩 粘合剂环氧乙烷/多元醇基复合体系，并更全面地了解 强调控制这些材料行为的科学原理。 密苏里大学堪萨斯城分校之间的合作努力 堪萨斯城中西部研究所的研究人员和调查员 3M 公司的研究人员生产力最高，并建立了 能够实现这一总体目标的必要的科学家骨干队伍。如果我们 如果我们成功了，我们将对低水平的行为有更深入的了解 应力/低收缩环氧乙烷/多元醇基复合材料系统。还有牙齿护理 为广大公众提供了极大的改善和合适的 将可以替代牙科用汞合金。