Novel surface treatment of fillers for dental composites

牙科复合材料填料的新型表面处理

• 批准号: 7030261
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 18.8万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7030261
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biotechnology; composite resins; dental adhesive /sealant; dental amalgam; dental caries; polymers; polymethacrylate; silanes; surface coating; tooth filling

DESCRIPTION (provided by applicant):The restoration of carious portions of otherwise sound teeth will continue to be a central focus of Dentistry into the foreseeable future. In spite of the significant improvements in composites over the last few decades, the projected service life of composite materials remains considerably less than that of Dental amalgams. Critical composite materials limitations are associated with shrinkage stress development during resin matrix formation and the establishment and long-term durability of the attachment between resin and filler. While many of the advances in composites have come from the selection of filler composition and particle size, the coupling agent interface between the resin and filler has received remarkably little attention. This proposed investigation will develop and evaluate the potential of an interfacial region that is dramatically different from that available with the conventional gamma-methacryloxypropyltrimethoxysilane used in Dental composites. In Specific Aim 1: controlled concentrations of functionalized silanes lacking polymerizable methacrylate groups will be applied to yield efficient surface coverage of small particle filler and microfiller. The silanization process will be studied in detail since significantly different application procedures can be used in the absence of methacrylate groups. In Specific Aim 2: the appended functionality will be used to covalently attach preformed oligomeric/polymeric chains. The surface-tethered chains can be significantly varied in terms of hydrophobicity, flexibility and length. In Specific Aim 3: the polymer brush surface-modified fillers will be formulated with traditional methacrylate-based Dental resins and the resulting composites will be evaluated with the reasonable expectation that the alternative coupling agents developed here will provide efficient and stable resin-filler attachment through both physical entanglements and direct copolymerization. Significant improvements are posited in composite materials based on higher filler loading, greater hydrolytic stability, increased wear resistance, improved fracture toughness and reduced polymerization shrinkage stress; all without compromise to mechanical strength properties. While the coupling agent makes up only a smell fraction of the Dental composite formulation, there appears to be substantial, clinically relevant benefits in composite performance that can potentially be obtained by changes in this interfacial region. Positive preliminary data offer encouragement that this nanotechnology approach to the resin-filler interface can provide broadly applicable enhancements in function and longevity of widely used Dental restoratives.

描述（由申请人提供）：在可预见的将来，恢复浮躁的牙齿的恢复将继续是牙科的核心重点。尽管在过去的几十年中，复合材料的显着改善，但复合材料的预计使用寿命仍然大大少于牙科汞合金。关键的复合材料限制与树脂基质形成期间的收缩应力发展以及树脂和填充物之间的附着的建立和长期耐用性有关。尽管复合材料的许多进展来自选择填充物组成和粒径，但树脂和填充剂之间的耦合剂界面的关注很少。这项提出的研究将开发和评估与牙科复合材料中使用的常规γ-甲基丙烯酰丙酰甲氧基硅烷可用的界面区域的潜力。在特定的目标1中：缺乏可聚合甲基丙烯酸酯基团的功能化硅烷的受控浓度将用于产生小颗粒填充剂和微填料的有效表面覆盖率。硅烷化过程将进行详细研究，因为在没有甲基丙烯酸酯基团的情况下可以使用显着不同的施用程序。在特定目标2中：附加功能将用于共价附着预先形成的低聚/聚合物链。表面管道链在疏水性，柔韧性和长度方面可能会有很大变化。在特定的目标3中：聚合物刷表面修饰的填充剂将用传统的甲基丙烯酸酯基树脂配制，并且将评估所得的复合材料，以合理的期望，即这里开发的替代耦合剂将通过物理缠结和直接共聚。基于较高的填充物，更大的水解稳定性，增加耐磨性，改善断裂韧性和减少聚合收缩应激的复合材料，对复合材料进行了显着改进；所有这些都不妥协机械强度。虽然耦合剂仅占牙科复合制剂的闻起来的一部分，但似乎在复合性能方面具有实质性的，临床上相关的好处，这可能会通过该界面区域的变化获得。积极的初步数据鼓励了这种纳米技术方法对树脂填充界面的方法可以为广泛使用的牙科修复剂的功能和寿命提供广泛适用的增强。