Monomers and nanogel to improve adhesive resin structural integrity/durability

用于提高粘合剂树脂结构完整性/耐久性的单体和纳米凝胶

• 批准号: 8581810
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 37.89万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8581810
• 关键词: Address; Adherence; Adhesions; Adhesives; Affect; Ammonium; Anti-Bacterial Agents; Attention; Binding Sites; Chemicals; Chemistry; Child; Clinical; Clinical Research; Collagen; Coupled; Dental; Dental Amalgam; Dental Enamel; Dental caries; Dentin; Dentists; Deterioration; Development Plans; Devices; Disease; Drug Formulations; Equilibrium; Esthetics; Failure; Fluorescent Probes; General Population; General Practices; General Practitioners; Generations; Generic Drugs; Goals; Hybrids; Image; Imaging Techniques; Life; Link; Location; Longevity; Matrix Metalloproteinases; Mechanics; Methods; NanoGel; Oral health; Outcome; Patients; Performance; Phase; Plant Resins; Polymers; Procedures; Process; Production; Property; Protocols documentation; Psychological reinforcement; Reliance; Resistance; Services; Sodium Chloride; Structure; System; Techniques; Time; Tooth structure; Uncertainty; Visit; Water; adhesive polymer; analytical tool; base; composite restoration; crosslink; density; dental adhesive; design; improved; monomer; nano; nanomechanical; nanoscale; novel; novel strategies; particle; polymerization; public health relevance; restoration; restorative composite; restorative dentistry; restorative treatment; seal; small molecule; sound; success; uptake

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to challenges imposed by wet bonding techniques, the potential for water-induced phase separation prior to, during or over extended intervals following polymerization of this critical interface, a strong, intact margin cannot currently be reliably obtained. This proposal describes the development plan for new water compatible monomers that compared with HEMA, offer the potential for improved reactivity, avoidance of phase separation and the production of chemically and mechanically sound polymer networks. A highly versatile technique has been developed for preparing nano-scale (10 - 30 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. The proposed project is constructed around three specific aims: 1) water-compatible monomers as alternatives to or in addition to HEMA will be developed as a means to better maintain homogeneity and high crosslink densities throughout adhesive resins; 2) the positive preliminary results with nanogel-modified adhesives will be extended into water-dispersible reactive nanogels that provide enhanced structural homogeneity and stability while introducing components that cannot be dispersed in water as free monomers; and 3) micro/nano-mechanical property characterization coupled with imaging of the adhesive layer and interfaces will be collectively used as an analytical tool to better understand structure and properties associated with the interaction between dentin and the adhesive resin in existing materials as well as the advanced adhesives proposed here. We expect to correlate the stabilization of the adhesive resin phase with collagen protection strategies that include collagen crosslinking, anti-bacterial activity and MMP-inhibiting properties based on the non-migrating nanogel platform. The application will provide an improved understanding of the strengths and weaknesses of existing adhesive systems, while developing new materials that address the significant current problems of structural stability and durability within the adhesive and hybrid layers of bonded dental restorations.

描述（由申请人提供）：每年在美国进行的超过1亿个牙科修复治疗中的大部分涉及树脂键合复合材料的放置，并且承认牙医的大部分时间都可以通过修订和更换这些修复剂来进行修订和更换这些材料，以提高临床诊所的材料。复合恢复不仅具有比牙科合干剂具有审美优势，而且还提供了一种将恢复与牙本质和搪瓷的粘合性粘合的手段。但是，由于湿粘合技术施加的挑战，在这种关键界面聚合后，在或过度延长的间隔之前或过度延长的间隔之前，目前无法可靠地获得强，完整的边缘。该提案描述了与HEMA相比的新水兼容单体的开发计划，为改善反应性，避免相位分离以及化学和机械性声音聚合物网络的产生提供了潜力。已经开发了一种用途广泛的技术，用于准备纳米级（10-30 nm）聚合物颗粒，并控制了分支，化学和反应性位点的位置。这些反应性纳米凝胶可以在高浓度的次级单体中易于分散，然后浸润并随后与前聚合物添加剂共聚。拟议的项目是围绕三个特定目的构建的：1）兼容水的单体作为替代品或除hema之外的替代方案，以便在整个粘合树脂中更好地维持同质性和高交叉链接密度； 2）纳米凝胶改性粘合剂的阳性初步结果将延伸到水透射性反应性纳米凝胶中，这些反应性纳米凝胶具有增强的结构均匀性和稳定性，同时引入无法以自由单体为生的成分； 3）微/纳米机械性能表征以及粘合剂层和界面的成像将共同使用作为分析工具，以更好地理解与牙本质与现有材料中牙本质和粘合剂之间相互作用以及此处提出的先进粘合剂中相互作用相关的结构和特性。我们期望将粘合剂树脂相的稳定与胶原蛋白保护策略相关联，包括胶原蛋白交联，抗菌活性和基于非迁移纳米凝胶平台的MMP抑制特性。该应用程序将对现有胶粘剂系统的优势和缺点有了深入的了解，同时开发了解决粘合牙科修复体粘合剂和混合层内结构稳定性和耐用性的重大问题的新材料。