Nanostructured Dental Composite Restorative Materials

纳米结构牙科复合修复材料

• 批准号: 7581081
• 负责人: J DAVID EICK
• 金额: $ 26.01万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7581081
• 关键词: Address; Alkalies; Area; Benchmarking; Caliber; Chemicals; Clinical; Coupling; Dental; Ethylene Oxide; Filler; Glass; Goals; Grant; Hardness; Hybrids; Institution; Lead; Longevity; Measurement; Mechanics; Methacrylates; Modification; Optics; Particle Size; Plant Resins; Polymers; Powder dose form; Process; Property; Public Health; Radio-Opaque; Refractive Indices; Research; Research Personnel; Resistance; Resources; Rheology; Silanes; Silicon Dioxide; Specific qualifier value; Stress; Surface; System; Tensile Strength; Testing; Time; Viscosity; Weight; aluminosilicate; base; bisphenol A; bisphenol F diglycidyl ether; experience; improved; innovation; meetings; nano; nanoparticle; nanostructured; particle; photopolymerization; polymerization stress; response; restoration; restorative material; silane; tetrahydrofuran; triethylene glycol dimethacrylate

DESCRIPTION (provided by applicant): The overall goal of this project is to develop an improved dental composite with low polymerization stress using nanoclay fillers producing improved mechanical properties combined with BisGMA/TEGDEMA and/or oxirane resins. This project is an interdisciplinary effort involving three separate institutions, UMKC, UMR, and Mo-Sci Company. Hypothesis 1 (nanoclay fillers) The addition of nanoclay fillers will improve the mechanical properties of the BisGMA/TEGDMA (50:50) and UVR6105/GY281/PTHF (48:48:4) resin systems. Specific Aim: To determine an optimum surface modification and concentration of nanoclay fillers in each polymer matrix system, (see hypothesis 2 below), in order to select a binder-nanoparticle system that will provide optimal mechanical properties in a hybrid filled composite (see hypothesis 3 below). Hypothesis 2 (stress-reducing polymer) The incorporation of a spiroorthocarbonate (TOSU) into two different matrix resins, Bisphenol-A-glycidyldimethacrylate (BisGMA)/ triethylene glycol dimethacrylate (TEGDMA) (50:50) and 3,4-epoxycyclohexylmethyl-3,4-epoxycyclo-hexylcarboxylate (UVR6105)/Diglycidyl ether of Bisphenol F (GY281)/Poly(tetrahydrofuran) (PTHF) (48:48:4), will reduce the polymerization stress of the neat resins. Specific Aim 1 To determine the most appropriate spiroorthocarbonate and the optimal addition level that will significantly reduce the polymerization stress of BisGMA/TEGDMA. The TOSUs will be added to the resin at weight percents of 0, 1, 5, 10, and 20%. Specific Aim 2 To add two appropriate TOSUs to the UVR6105/GY281/PTHF (48:48:4) resin. The TOSUs will be added in concentrations as specified in Specific Aim 1. Hypothesis 3 (glass fillers) The addition of radio-opaque REAS glass fillers to the matrix resins, will produce a nano-hybrid composite with superior mechanical properties to current dental composites. Specific Aim 1 Select an appropriate alkali-free rare-earth aluminosilicate (REAS) glass that matches the refractive index of the cured resins. This glass will be processed into glass powder of appropriate particle size distribution (PSD) having average diameter between 0.05 and 5 microns. Specific Aim 2 Surface-treat the glass fillers with an appropriate coupling agent (either silane, or titanate or zirconate) will be incorporated into the matrix resin. Criteria for incorporation will include the surface treatment, PSD of the glass particles, and loading level of the glass particles into the composite. Specific aim 3 Compare properties (mechanical, optical, chemical) of alkali-free rare-earth REAS glass-modified composites to commercial dental composites. Successful completion of the proposed research will result in significant contributions to dental public health, including: (a) a restorative with significantly reduced polymerization stress which should increase the durability and longevity of the restoration; (b) a restorative with enhanced depth of cure that can be bulk placed which will save clinical time and resources; and (c) a significantly improved understanding of methacrylate and oxirane-based polymeric materials containing nano-fillers.

描述（由申请人提供）：该项目的总体目标是开发一种具有低聚合应力的改进牙科复合材料，使用纳米粘土填料与 BisGMA/TEGDEMA 和/或环氧乙烷树脂相结合，产生改进的机械性能。该项目是一个跨学科的项目，涉及三个独立的机构：UMKC、UMR 和 Mo-Sci Company。假设1（纳米粘土填料） 纳米粘土填料的添加将改善BisGMA/TEGDMA（50:50）和UVR6105/GY281/PTHF（48:48:4）树脂体系的机械性能。具体目标：确定每个聚合物基体系统中纳米粘土填料的最佳表面改性和浓度（参见下面的假设 2），以便选择能够在混合填充复合材料中提供最佳机械性能的粘合剂-纳米颗粒系统（参见假设3 下）。假设 2（减压聚合物） 将螺原碳酸酯 (TOSU) 掺入两种不同的基体树脂：双酚 A-二甲基丙烯酸缩水甘油酯 (BisGMA)/ 三甘醇二甲基丙烯酸酯 (TEGDMA) (50:50) 和 3,4-环氧环己基甲基-3 ,4-环氧环己基羧酸酯(UVR6105)/双酚F二缩水甘油醚(GY281)/聚四氢呋喃(PTHF)(48:48:4)，将降低纯树脂的聚合应力。 具体目标 1 确定最合适的螺原碳酸酯和最佳添加量，以显着降低 BisGMA/TEGDMA 的聚合应力。 TOSU 将以 0、1、5、10 和 20% 的重量百分比添加到树脂中。具体目标 2 将两种适当的 TOSU 添加到 UVR6105/GY281/PTHF (48:48:4) 树脂中。 TOSU 将按具体目标 1 中指定的浓度添加。 假设 3（玻璃填料） 将不透射线 REAS 玻璃填料添加到基体树脂中，将产生一种纳米混合复合材料，其机械性能优于现有牙科复合材料。具体目标 1 选择与固化树脂的折射率相匹配的合适的无碱稀土铝硅酸盐 (REAS) 玻璃。该玻璃将被加工成平均直径在0.05至5微米之间的适当粒度分布(PSD)的玻璃粉末。具体目标 2 用适当的偶联剂（硅烷、钛酸酯或锆酸酯）对玻璃填料进行表面处理，将其掺入基体树脂中。掺入标准包括表面处理、玻璃颗粒的 PSD 以及玻璃颗粒在复合材料中的负载水平。具体目标 3 比较无碱稀土 REAS 玻璃改性复合材料与商用牙科复合材料的性能（机械、光学、化学）。成功完成拟议的研究将为牙科公共卫生做出重大贡献，包括：（a）聚合应力显着降低的修复体，这将提高修复体的耐用性和寿命； (b) 具有增强固化深度的修复体，可以批量放置，从而节省临床时间和资源； (c) 显着提高对含有纳米填料的甲基丙烯酸酯和环氧乙烷基聚合物材料的理解。