BAS and Bipolar Spectrum: Biopsychosocial Integration

BAS 和双极谱：生物心理社会整合

• 批准号: 6576980
• 负责人: LYN Y ABRAMSON
• 金额: $ 40.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6576980
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; clinical research; cognition; cyclothymia; disease /disorder onset; electroencephalography; human subject; interview; lifestyle; longitudinal human study; major depression; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; pathologic process; personality; psychobiology; psychological tests; psychopathology; relapse /recurrence; social psychology; social support network

DESCRIPTION (provided by applicant): This application is part of a 2-site collaborative renewal grant with an identical (except for budget/personnel) application submitted concurrently by Dr. Lauren B. Alloy (Temple University) under the same title. Although important biological work has been conducted on Bipolar (Bi) disorder, less work has examined psychosocial factors in the onset, course, and progression of this disorder. Thus, in this proposal, theories implicating the Behavioral Approach System (BAS) in Bi Spectrum disorders are integrated with work on psychosocial factors in these conditions to provide a theoretically consistent and methodologically rigorous biopsychosocial framework to guide a prospective study of the course and progression of Bi disturbance. In the current grant, a unique sample of 206 Ss initially exhibiting milder Bi disturbance (Cyclothymia [Cyc] and Bi II), many of whom now are progressing to a more severe course, and 214 demographically-matched Normal controls (Nors) with no lifetime history of any psychopathology has been assembled and followed prospectively for an average of 21 months with independent and blind self-report and interview assessments (every 16 weeks) of life events, cognition, and psychiatric status/symptoms. At the outset of the proposed continued follow-up of this sample, laboratory assessments of BAS profiles, both in the resting state and in response to BAS-relevant cues, using psychophysiological (EEG assessments of left frontal cortical activity), behavioral (task persistence vs. helplessness), cognitive (self-efficacy/hopefulness vs. hopelessness), and subjective affect (euphoria, anger/irritability, depression) indices will be conducted to test the hypothesis that Bi Ss exhibit dysregulated BAS activity compared to Nor Ss. Moreover, life events, with a focus on those that are BAS-relevant, laboratory BAS profile, and cognitive vulnerability will be examined in the prediction of -Hypomania/Mania and Depression symptoms and episodes among Bi and Nor Ss in the continued 3-year prospective follow-up. Finally, these same factors will be examined to predict general worsening of course and progression to Bi II and Bi I status among the Bi Ss.

描述（由申请人提供）：此申请是由相同标题的Lauren B. Alloy（Temple University）同时提交的相同（预算/人员）申请的2个站点合作裁员赠款的一部分。 尽管已经对双极（BI）疾病进行了重要的生物学工作，但较少的工作检查了这种疾病的发作，过程和进展中的社会心理因素。因此，在本提案中，在BI谱系障碍中暗示行为方法系统（BAS）的理论与这些条件下的心理社会因素的工作融合在一起，以提供理论上一致且在方法论上严格的生物心理社会框架，以指导对BI扰动过程和进展的前瞻性研究。 In the current grant, a unique sample of 206 Ss initially exhibiting milder Bi disturbance (Cyclothymia [Cyc] and Bi II), many of whom now are progressing to a more severe course, and 214 demographically-matched Normal controls (Nors) with no lifetime history of any psychopathology has been assembled and followed prospectively for an average of 21 months with independent and blind self-report and interview assessments (every 16 weeks) of life events, cognition, and精神病状态/症状。在提出的样本持续随访时，使用心理生理学（EEG评估左侧皮质活动），行为（任务持久性与隐藏性），认知能力/希望/希望的愤怒（expirial Inlupe）（eeg and Inperiative anderigantive and and and andimentive anderigantive and and and and and and and and and and and and and and and and and and and and andimiage andimigantive and and andimigantive and and and and and and and and and and and and and and and and ander，愤怒（E）将进行测试，即BI SS与NOR SS相比表现出失调的BAS活性。此外，将在持续3年的前瞻性随访中，将检查生活事件，重点关注与基于基础，实验室BAS概况和认知脆弱性的事件。最后，将检查这些相同的因素，以预测BI SS中BI II和BI I状态的总体恶化和进展。