DST and Suicide Prediction

夏令时和自杀预测

• 批准号: 6619524
• 负责人: ELIZABETH ANN YOUNG
• 金额: $ 26.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-25 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6619524
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; clinical research; cortisol; dexamethasone suppression test; disease /disorder proneness /risk; gender difference; human data; human mortality; major depression; male; mental health information system; method development; psychometrics; suicide

DESCRIPTION (provided by applicant): Suicide is a major public health problem in the US. To date, the main risk factors identified in multiple clinical samples include male sex, living alone and suicidal ideation. Recent data suggest that demonstrating non-suppression to cortisol on the dexamethasone suppression test (DST) may be a more robust clinical predictor than these other variables. This is further supported by post-mortem data indicating chronic activation of the HPA axis such as increased adrenal weight and increased POMC mRNA in the anterior pituitary. Furthermore, strong evidence supports the effects of cortisol in modulating brain serotonin systems. This project depends upon the existence of a large database of subjects with the diagnosis of major depression who received the DST between 1978 and 1987. All subjects also received SADS interviews and weekly Ham-D ratings during assessment and follow-up. After identifying index cases, we will examine mortality rates particularly suicide in DST positive and negative subjects as well as examining the relationship between a number of other potential risk factors for suicide and completed suicide.

描述（申请人提供）：自杀是一个主要的公共卫生问题 在美国。迄今为止，在多个临床中确定的主要风险因素 样本包括男性，独自生活和自杀念头。最新数据 建议在地塞米松上证明对皮质醇的不抑制 抑制测试（DST）可能是比其他更强大的临床预测因子 变量。验尸数据进一步支持了这一点，表明慢性 HPA轴的激活，例如增加肾上腺重量和POMC增加 前垂体中的mRNA。此外，有力的证据支持 皮质醇在调节脑血清素系统中的影响。这个项目取决于 在存在大型受试者数据库之后 在1978年至1987年之间接受了DST的抑郁症。 在评估期间获得了SADS访谈和每周HAM-D评级 后续。确定指数案件后，我们将检查死亡率 特别是在DST正面和负面主题中自杀以及检查 自杀的许多其他潜在风险因素之间的关系 并完成自杀。