Substance Abuse in ADHD Girls

多动症女孩的药物滥用

• 批准号: 6625813
• 负责人: Timothy E Wilens
• 金额: $ 17.3万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-05 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6625813
• 关键词: academic achievement; adolescence (12-20); alcoholism /alcohol abuse; attention deficit disorder; behavior prediction; behavioral /social science research tag; bipolar depression; comorbidity; conduct disorder; disease /disorder onset; disease /disorder proneness /risk; family genetics; family structure /dynamics; female; gender difference; human subject; mental health epidemiology; neuropsychological tests; patient oriented research; smoking; socioenvironment; substance abuse epidemiology; substance abuse related disorder; tobacco abuse; women's health; young adult human (21-34)

This is the first resubmission of an R01 application, 1 R01 DA14419-01, that is a response to a PA (97-043) encouraging research on the origins and pathways to substance abuse (SA). A mixed body of evidence suggests that SA is frequently preceded by childhood attention-deficit/hyperactivity disorder (ADHD) and associated comorbid disorders. The aim of this proposal is to test hypotheses about the co-occurrence of SA in ADHD adolescent girls growing up and their high-risk siblings. We are proposing to study a group of girls available from an NIMH funded five year, family-based, controlled follow-up study of girls with ADHD currently underway with a focus on SA. At baseline assessment, we ascertained 140 ADHD and 120 normal control girls from psychiatric and non-psychiatric settings with 464 and 402 first degree biological relatives, respectively. We now propose a five-year study that will re-examine the probands and families five years after their baseline assessment with a particular emphasis on SA, thus capturing these adolescents as they are beginning to pass through the risk for SA. We have two Main Aims: 1) To characterize SA in ADHD girls growing up, and 2) To determine predictors of SA in ADHD girls growing up. In our preliminary work, we have begun to address issues related to the overlap of SA and ADHD in boys and girls that are the focus of the proposed work. We view the proposed extension of our work as an essential step for several reasons: this work will be the first, prospective high risk family-based study of SA in ADHD girls; we will have extensive information on a well characterized group of children ascertained from medical and psychiatric settings spanning five years; and psychiatric comorbidity within ADHD was not excluded allowing analysis of its influence on later SA. Given the high prevalence of ADHD, its related comorbid disorders, and its frequent persistence into adulthood, the proposed study will shed light on ADHD adolescent and young adult females at highest risk for SA. Since ADHD is treatable and identifiable in early years, these data will provide valuable information to formulate prevention interventions. Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority.

这是R01应用程序1 R01 DA14419-01的第一次重新提交，这是对PA（97-043）的回应，鼓励对药物滥用的起源和途径（SA）进行研究。 大量证据表明，SA经常在儿童注意力缺陷/多动症（ADHD）和相关的合并症之前。 该提案的目的是检验有关SA在ADHD青春期女孩和高风险兄弟姐妹中的同时出现的假设。 我们建议研究一群来自NIMH资助的NIMH五年，基于家庭的，受控的随访研究，目前正在进行多动症的女孩，重点是SA。 在基线评估时，我们确定了140个ADHD和120名正常对照女孩，分别具有464和402一级生物亲戚的精神和非精神病学环境。现在，我们提出了一项为期五年的研究，该研究将在基线评估后五年重新检查概率和家庭，并特别强调SA，从而捕获这些青少年，因为他们开始经历SA的风险。 我们有两个主要目的：1）在成长的多动症女孩中表征SA，以及2）确定ADHD Girls中SA的预测因素。 在我们的初步工作中，我们开始解决与拟议工作重点的男孩和女孩相关的与SA和ADHD重叠有关的问题。由于多种原因，我们认为拟议扩展我们的作品是必不可少的一步：这项工作将是对ADHD Girls中SA的第一个前瞻性高风险家庭研究；我们将获得有关从五年的医学和精神病学中确定的一组有特色的儿童群体的广泛信息； ADHD中的精神病合并症并未被排除在外，允许分析其对以后的SA的影响。 鉴于多动症的高患病率，其相关的合并症及其频繁的持久性，拟议的研究将揭示出ADHD青少年和年轻的成年女性，其SA的风险最高。 由于ADHD在早期是可以治疗和可识别的，因此这些数据将提供有价值的信息以制定预防干预措施。 因此，该R01应用程序的研究，方法和目标与PA中强调的研究所以及医学研究所是最高的研究优先事项。