2 FORMS OF UVRC AND THEIR ROLES IN REPAIR OF DNA DAMAGE

2 UVRC 的形式及其在修复 DNA 损伤中的作用

• 批准号: 6342570
• 负责人: Eric Moon-shong M. TANG
• 金额: $ 17.51万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342570
• 关键词: DNA damage; DNA directed DNA polymerase; DNA repair; Escherichia coli; acetylaminofluorene; carcinogen testing; chemical carcinogenesis; cofactor; enzyme activity; gel filtration chromatography; gene induction /repression; high performance liquid chromatography; microorganism culture; mutagen testing; nucleic acid sequence; phosphoproteins; posttranslational modifications; protein structure function; radiation carcinogenesis; radiation genetics; recombinase; transfection; ultraviolet radiation

项目成果

The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma.

主要的脂质过氧化产物反式4-羟基-2-壬烯醛优先在人p53基因的密码子249处形成DNA加合物，这是肝细胞癌中独特的突变热点。

• DOI: 10.1093/carcin/23.11.1781
• 发表时间: 2002-11-01
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Wenwei Hu;Zhaohui Feng;Jamie F. Eveleigh;G. Iyer;Jishen Pan;S. Amin;F. Chung;M. Tang
• 通讯作者: M. Tang

Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene.

使用 UvrABC 核酸酶定量 p53 基因中甲基化与非甲基化 CpG 位点的苯并[a]芘二醇环氧化物-DNA 加合物形成。

• DOI: 10.1093/carcin/20.6.1085
• 发表时间: 1999-06-01
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Moon;Jessica B Zheng;M. Denissenko;Gerd P. Pfeifer;Yi Zheng
• 通讯作者: Yi Zheng

Cyclobutane pyrimidine dimers and bulky chemical DNA adducts are efficiently repaired in both strands of either a transcriptionally active or promoter-deleted APRT gene.

环丁烷嘧啶二聚体和庞大的化学 DNA 加合物在转录活性或启动子缺失的 APRT 基因的两条链中得到有效修复。

• 发表时间: 2001-05-18
• 作者: Zheng, Y;Pao, A;Adair, G M;Tang , M
• 通讯作者: Tang , M

Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis.

Trans-4-羟基-2-壬烯醛抑制人类细胞中的核苷酸切除修复：脂质过氧化诱导致癌的可能机制。

• DOI: 10.1073/pnas.0402794101
• 发表时间: 2004-06-08
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Zhaohui Feng;Wenwei Hu;M. Tang
• 通讯作者: M. Tang

Sequence-dependent interactions of two forms of UvrC with DNA helix-stabilizing CC-1065-N3-adenine adducts.

两种形式的 UvrC 与 DNA 螺旋稳定 CC-1065-N3-腺嘌呤加合物的序列依赖性相互作用。

• DOI: 10.1021/bi010953p
• 发表时间: 2001-09-18
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: M. Nazimiec;C. S. Lee;Y. L. Tang;X. Ye;R. Case;M. Tang
• 通讯作者: M. Tang