Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans

ADRD 风险中的大脑健康和种族差异：阿拉伯裔美国人的案例

• 批准号: 10605196
• 负责人: KRISTINE J. AJROUCH
• 金额: $ 159.64万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605196
• 关键词: Address; Age; Aging; Alzheimer' s disease related dementia; American; Arabs; Biological Markers; Black American; Black Populations; Blood; Brain; Clinical; Cognitive; Cognitive aging; Data; Development; Diabetes Mellitus; Dimensions; Disadvantaged; Disparity; Disparity population; Ensure; Ethnic Origin; Ethnic Population; Funding; Genetic; Geographic Locations; Health; Hippocampus; Hispanic Populations; Hypertension; Immigrant; Incidence; Inequality; Intervention; Knowledge; Link; Magnetic Resonance Imaging; Mediating; Memory; Mental Depression; Mental Health; National origin; Neurologic; Not Hispanic or Latino; Outcome; Parents; Participant; Phenotype; Prevalence Study; Prevention strategy; Race; Religion; Research; Resources; Risk; Risk Factors; Sampling; Severities; Social Network; Social support; Structure; Testing; Time; White Matter Hyperintensity; Work; aged; aging brain; apolipoprotein E-4; brain health; cognitive function; comparative; dementia risk; disparity elimination; ethnic difference; ethnic disparity; experience; health data; health disparity; magnetic resonance imaging biomarker; migration; neuroimaging; physical conditioning; predictive marker; prevention evaluation; protective factors; racial difference; racial disparity; racial population; response; social; social culture; social factors; social group; social influence; sociocultural determinant; stressor; virtual

Project Summary Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans The incidence of Alzheimer’s disease and related dementia (ADRD) is higher in Black Americans and Hispanics than in non-Hispanic Whites, but data on Arab Americans have been virtually absent from research on brain and cognitive aging. The unique experiences of this understudied group have the potential to clarify knowledge of ADRD disparities related to ethnicity, immigrant and social factors. The proposed project leverages the first prevalence study of ADRD among Arab Americans (AG057510) to examine brain mechanisms underlying links between sociocultural risk/protective factors and ADRD. The purpose of this research is to investigate the links between immigrant/cultural factors, brain health, and clinical outcomes related to ADRD. The following specific aims will be accomplished by obtaining structural MRI and blood-based AD biomarker data in the Detroit-Aging and Memory Project (D-AMP), which obtains high-quality ADRD phenotypes and genetic data on those aged 65+ from a representative sample of 600 Arab Americans, as well as panel participants (N=298) from the Social Relations Study (SRS), to compare to samples of non-Arab Whites in the same geographic area. Our specific aims are: 1) Quantify differences in brain aging among Arab Americans and Whites in metro-Detroit and determine the contribution of brain health to group differences in ADRD; 2) Determine the contribution of immigrant/cultural factors (e.g., national origin, age of migration) to brain aging among Arab Americans; 3) Characterize the influence of social relations on brain and cognitive aging among Arab Americans and Whites. The proposed study benefits from exceptional circumstances, leveraging a uniquely available sample and data, to characterize, for the first time, neuroimaging and blood-based AD biomarkers among older Arab Americans. This knowledge is critical for the development and evaluation of prevention and intervention strategies, as well as the cultural tailoring of such efforts to ensure efficacy in different sociocultural groups in order to eliminate disparities.

项目摘要 ADRD风险中的大脑健康和种族差异：阿拉伯美国人的案例 在黑人美国人和 西班牙裔与非西班牙裔白人相比，但实际上缺乏有关阿拉伯美国人的数据 关于大脑和认知衰老。这个理解的小组的独特经历有可能澄清 与种族，移民和社会因素有关的ADRD差异的知识。拟议的项目 利用阿拉伯美国人（AG057510）中ADRD的首次患病率研究检查大脑 社会文化风险/保护因素与ADRD之间联系的机制。这个目的 研究是为了研究移民/文化因素，大脑健康和临床结果之间的联系 与Adrd有关。以下特定目的将通过获得结构MRI和基于血液来实现 底特律与内存项目（D-AMP）中的AD生物标志物数据，该数据获得了高质量的ADRD 同样来自600名阿拉伯美国人的代表性样本的65岁以上的表型和遗传数据 作为社会关系研究（SRS）的小组参与者（n = 298），与非阿拉伯的样本进行比较 白人在同一地理区域。我们的具体目的是： 1）量化阿拉伯裔美国人和白人的大脑衰老差异，并确定 大脑健康对ADRD组差异的贡献； 2）确定移民/文化因素（例如国籍，移民年龄）对大脑的贡献 阿拉伯美国人的老化； 3）表征社会关系对阿拉伯美国人和认知衰老的影响 白人。 拟议的研究受益于特殊情况，利用独特的样本和数据， 为了表征阿拉伯年龄较大的美国人中的神经影像学和基于血液的AD生物标志物。 这些知识对于预防和干预策略的发展和评估至关重要 作为确保不同社会文化群体效率的这种努力的文化剪裁，以消除 差异。