Solid State Beta Imaging Sensor for Image Guided Surgery

用于图像引导手术的固态 Beta 成像传感器

• 批准号: 6616735
• 负责人: GERALD ENTINE
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6616735
• 关键词: beta radiation; bioimaging /biomedical imaging; biomedical equipment development; biopsy; charge coupled device camera; digital imaging; image guided surgery /therapy; imaging /visualization /scanning; mathematical model; nuclear medicine; radio; radiotracer; surgery material /equipment

DESCRIPTION (provided by applicant): Nuclear Medicine imaging has been widely used to preoperatively image structures of interest for excisional biopsy. Radio-guided intraoperative procedures utilizing radiotracers have facilitated a cost-effective, highly specific means to locate suspect tissue and access it for pathologic analysis. The result of radio-guided surgery is increased tissue specificity obtained for biopsy, minimally accessed incisions, and the reduction of inpatient hospital utilization with an improved patient recovery. Nuclear medicine based surgical guidance with non-imaging gamma detector probes is gaining in acceptance and popularity. The main drawback of non-imaging guidance is the lack of ancillary information of the surveyed area, such as distinction between two neighboring radioactive regions, which can be overcome with an intraoperative imaging probe. Also, the highly penetrating gamma radiation arising from other parts of the body increases the background and limits the practical use of these probes. We propose to address these limitations by designing a new-generation intraoperative probe intended to rapidly image the tumor bed with short-range beta rays. This new design will be based on a solid-state, compact readout sensor coupled to a high resolution, high SNR converter. When developed, this detector will allow accurate delineation of the tumor, thus facilitating precise resection. PROPOSED COMMERCIAL APPLICATIONS: Advances in radiopharmaceuticals has dramatically escalated the use of intraoperative probes in surgery. The proposed research will provide a new class of digital imaging probes, which will exploit these advances allowing for complete and accurate tumor resection with enhanced quality of health care and increased lifespan of patients. This new imaging technology has enormous potential in both medical and non-medical applications. The estimated market size for probes is well over a hundred million dollars. A significant fraction of this market represents areas where the proposed technology will have a major impact.

描述（由申请人提供）： 核医学成像已被广泛用于术前图像 兴奋的解剖活检的结构。无线电引导的术中 利用放射性示例的程序有助于成本效益 定位可疑组织并访问病理分析的特定手段。 无线电指导手术的结果是增加的组织特异性 进行活检，最小访问的切口和住院减少 医院利用，改善患者康复。 基于核医学的手术指导，非成像伽马检测器 探针正在接受和受欢迎。主要缺点 非成像指导是缺乏调查的辅助信息 区域，例如两个相邻放射性区域之间的区别， 可以通过术中成像探针克服。另外，高度 由身体其他部位引起的穿透性伽马辐射增加了 背景和限制了这些探针的实际使用。 我们建议通过设计新一代来解决这些限制 术中探针旨在快速对肿瘤床迅速成像 beta射线。这种新设计将基于固态，紧凑的读数 传感器耦合到高分辨率高SNR转换器。开发时，这个 检测器将允许准确描述肿瘤，从而促进 精确切除。 拟议的商业应用： 放射性药物的进步大大升级了手术中术中探针的使用。拟议的研究将提供一类新的数字成像探针，这些探针将利用这些进步，从而可以通过增强的医疗保健质量和患者的寿命增加进行完整而准确的肿瘤切除。这项新的成像技术在医学和非医疗应用中具有巨大的潜力。探针的估计市场规模远远超过一亿美元。该市场的很大一部分代表了拟议技术将产生重大影响的领域。

项目成果

Suppression of Afterglow in Microcolumnar CsI:Tl by Codoping With Sm: Recent Advances.

• DOI: 10.1109/tns.2009.2016198
• 发表时间: 2009-01-01
• 期刊: IEEE transactions on nuclear science
• 影响因子: 1.8
• 作者: Nagarkar VV;Thacker SC;Gaysinskiy V;Ovechkina LE;Miller SR;Cool S;Brecher C
• 通讯作者: Brecher C

A hand-held beta imaging probe for FDG.

• DOI: 10.1007/s12149-012-0672-6
• 发表时间: 2013-04
• 期刊: ANNALS OF NUCLEAR MEDICINE
• 影响因子: 2.6
• 作者: Singh, Bipin;Stack, Brendan C., Jr.;Thacker, Samta;Gaysinskiy, Valeriy;Bartel, Twyla;Lowe, Val;Cool, Steven;Entine, Gerald;Nagarkar, Vivek
• 通讯作者: Nagarkar, Vivek