Imaging System for Brachytherapy Source Characterization

用于近距离放射治疗源表征的成像系统

• 批准号: 6337642
• 负责人: YU-TARNG CHENG
• 金额: $ 10万
• 依托单位: NEUTEK
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2002-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337642
• 关键词: beta radiation; bioimaging /biomedical imaging; biomedical equipment development; gamma radiation; imaging /visualization /scanning; neoplasm /cancer radionuclide therapy; phosphorus; radiation detector; radiation dosage; radiopharmacology

DESCRIPTION (Provided by Applicant): This program's purpose is to develop an imaging device for characterization of the radioactivity distribution of brachytherpy sources used in cancer treatment. The new device will utilize storage photostimulable phosphor (SPP) technology, widely available in radiology and oncology departments, to measure the 3-dimensional radiation profile of a brachytherapy source. A SPP sensor will serve as a high resolution radiation detector. The device will be able to apply to both gamma and beta emitting sources. The end product is a fast, accurate and low-cost 3-dimensional imaging system for mapping the volumetric radioactivity profiles of brachytherapy sources. This information is critical to the delivering of quality cancer treatment and will help improve the quality of brachytherapy source manufacturing. In Phase I, a 2-dimensional system will be constructed and tested using a pin-hole camera concept to measure surface and near-field source radioactivity. The results will be independently confirmed via comparison with measures obtained by conventional methods. Expanding on the camera concept, in Phase II, a panoramic 3600 view camera will be designed to map a 3-dimensional radioactivity profile of brachytherapy sources. This multi-pin-hole camera will record simultaneously from all respects the radioactivity distribution of a brachytherapy source. The goal for the multi-pin hole camera is to advance from a 2-dimensional camera design to a 3-dimensional one without resulting in longer exposure time or lower resolution. PROPOSED COMMERCIAL APPLICATION: The proposed imaging technology has the potential to be used at over 1,000 medical facilities in the United States alone. Using the imaging device to improve the production of brachytherapy sources and ensure proper delivery of an accurate dosage to the patient can greatly enhance the ability of physicians worldwide to treat a wide variety of cancers. Interest in the technology is also high across may other disciplines, including biomedical, computer and physical science.

描述（由申请人提供）：该程序的目的是开发 成像设备，用于表征放射性分布 癌症治疗中使用的黄牙源。新设备将使用 存储光刺激磷光器（SPP）技术，广泛可用 放射学和肿瘤学部门，以测量3维辐射 近距离放射治疗来源的轮廓。 SPP传感器将用作高分辨率 辐射探测器。该设备将能够应用于伽马和beta 发出的来源。最终产品是快速，准确且低成本的 用于映射体积放射性曲线的三维成像系统 近距离放射治疗的来源。此信息对于交付至关重要 优质的癌症治疗，将有助于提高近距离放射治疗的质量 来源制造。 在第一阶段，将使用A二维系统构建和测试 针孔相机概念，以测量表面和近场源放射性。 结果将通过与度量进行比较独立确认 通过常规方法获得。在第二阶段的相机概念上扩展 全景3600视图摄像头将设计用于绘制3维 近距离放射治疗来源的放射性特征。这个多针孔相机将 从所有方面同时记录A的放射性分布 近距离放射治疗来源。多针孔相机的目标是从 二维摄像机设计，可用于三维的摄像机设计 较长的暴露时间或较低的分辨率。 拟议的商业应用： 拟议的成像技术有可能在1000多个医疗中使用 仅美国的设施。 使用成像设备改善 近距离放射治疗来源并确保正确送给患者的精确剂量 可以大大提高全球医生治疗各种癌症的能力。 在5月的其他学科中，对技术的兴趣也很高，包括生物医学， 计算机和物理科学。