CONSTRUCTION OF ANIMAL FACILITY

动物设施建设

• 批准号: 6508230
• 负责人: PETER J DAVIES
• 金额: $ 300万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6508230
• 关键词: CONSTRUCTION; ANIMAL; FACILITY

DESCRIPTION (provided by applicant): This application requests support for construction of a permanent facility for housing, breeding and care of genetically engineered (transgenic and knockout) and immuno-compromised rodents. The facility will be located in a new research building being designed by the UTHSC-H. UTHSC-H Investigators hold approximately $100 million (total costs) of active National Institutes of Health (NIH)-funding for studies involving animals, and $7 million in yearly direct costs for active and pending studies with specialized mice. Tropical Storm Allison totally destroyed the Animal Care Center that housed most of the animals used for this research. Tragically, hundreds of animals drowned. To prevent this from ever happening again, the proposed facility will be on the top floor of a new nine-story building. The new building will have enclosed connections to the UTHSC-H Medical School and Institute for Molecular Medicine Buildings, so that it will support the work of investigators in all three buildings. The proposed facility will contain 5,945 sq. ft., including a large barrier suite, for genetically engineered and immuno-comprised rodents. It will occupy roughly half a floor devoted exclusively to animal care and accommodate up to 11,000 animals. The facility will be under the control of the Center for Laboratory Animal Medicine and Care (CLAMC), which manages and operates all animal care and use activities at the UTHSC-H. The CLAMC was initially accredited by the AAALAC International in 1978 and remains fully accredited today. The Director of the CLAMC reports directly to the Executive Vice President for Research of the UTHSC-H.

描述（由申请人提供）：本申请请求支持建设永久性设施，用于饲养、繁殖和护理基因工程（转基因和基因敲除）和免疫受损的啮齿动物。 该设施将位于由 UTHSC-H 设计的一座新研究大楼内。 UTHSC-H 的研究人员拥有大约 1 亿美元（总成本）的美国国立卫生研究院 (NIH) 活跃资金，用于涉及动物的研究，以及每年 700 万美元的直接成本，用于正在进行的和悬而未决的专门小鼠研究。 热带风暴艾利森完全摧毁了动物护理中心，该中心饲养着用于这项研究的大部分动物。 不幸的是，数百只动物被淹死。 为了防止这种情况再次发生，拟议的设施将位于一栋新的九层建筑的顶层。 新大楼将与 UTHSC-H 医学院和分子医学研究所大楼建立封闭连接，以便支持所有三栋大楼的研究人员的工作。 拟议的设施将占地 5,945 平方英尺，包括一个大型屏障套件，用于基因工程和免疫啮齿动物。 它将占据大约半层楼，专门用于动物护理，可容纳多达 11,000 只动物。 该设施将由实验动物医学和护理中心 (CLAMC) 控制，该中心负责管理和运营 UTHSC-H 的所有动物护理和使用活动。 CLAMC 最初于 1978 年获得 AAALAC International 的认可，至今仍获得完全认可。 CLAMC 主任直接向 UTHSC-H 的研究执行副总裁报告。