Regional Biocontainment Laboratories Facility and Building System Upgrades Support

区域生物防护实验室设施和建筑系统升级支持

• 批准号: 10392181
• 负责人: Colin S. Duckett
• 金额: $ 332.99万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392181
• 关键词: Address; Air; Animal Experimentation; Animal Model; Basic Science; Biological Assay; Cell Separation; Cells; Certification; Chemicals; Communicable Diseases; Computer Security; Computer software; Containment; Contractor; Contracts; Core Facility; Custom; Diagnostic; Disease Outbreaks; Emerging Communicable Diseases; Engineering; Equipment; Facility Design and Construction; Facility Designs; Funding; Goals; Grant; Infection; Infectious Diseases Research; Infrastructure; International; Laboratories; Leadership; Maintenance; Modernization; Monitor; Mus; Performance; Pharmaceutical Preparations; Recovery; Research; Research Personnel; Resources; Security; Service provision; Services; Solid; System; Testing; Time; Trust; United States National Institutes of Health; Universities; Vaccines; Vendor; aged; biocontainment facility; biodefense; cost; design; design and construction; innovation; laboratory facility; medical schools; operation; pressure; prevent; programs; repaired

Project Summary/Abstract: The Duke Regional Biocontainment Laboratory (RBL) was constructed with funding from the National Institutes of Health (NIH) to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. The state-of-the-art biocontainment facility, designed to support lab and small animal research, was fully commissioned and opened for operation in 2007 on the Duke University Medical School Campus in Durham, NC. The Duke RBL facility supports grant/contract-funded investigators and also provides biocontainment labs, innovative host monitoring assays and small animal models through Core Service Center Units on a cost recovery basis. Fourteen years of use and time have rendered some of the Duke RBL facilities, systems and critical core research equipment obsolete, or in need of repair, replacement or modernization. We have identified six critical deficiencies of the facility’s existing physical infrastructure that limit biosafety, security or threaten the provision of services it offers and research-related activities it supports. We will address these deficiencies in our three Specific Aims: 1) Modernize Building Air Control Systems – Upgrade obsolete BSL3/ABSL3 building controls systems, pressure monitors and software. Rebalance, test, validate and re-certify all impacted BSL3/ABSL3 space; 2) Modernize Biosafety and Security Systems - Replace aged/damaged biosafety cabinets in BSL2/BSL3/ABSL3 laboratories. Repair and upgrade components of the BSL3 chemical effluent treatment system. Replace damaged or obsolete closed circuit security cameras, cabling and integration with building security control systems; and 3) Modernize Research Resources – Replace the obsolete high-containment cell sorter and custom Bioprotect hood in the BSL3 Cell Sorting Core facility. Upgrade the blower control modules on the Allentown Biocontainment mouse cage racks in the ABSL3. These Aims/Goals will be accomplished by a highly integrated project management team with solid institutional support and trusted contractors/vendors that were part of the original design and construction of the facility and/or have been part of the continuous maintenance, repair and certification of the facility for the past 14 years.

项目摘要/摘要： 杜克大学地区生物防护实验室 (RBL) 是在美国国立研究院的资助下建造的 卫生署 (NIH) 支持开发药物、诊断方法和疫苗所需的基础研究 新出现/重新出现的感染和生物防御。最先进的生物防护设施，旨在 支持实验室和小动物研究，于 2007 年在杜克大学全面投入运行并开放运营 北卡罗来纳州达勒姆大学医学院校园杜克大学 RBL 设施支持赠款/合同资助。 研究人员还提供生物防护实验室、创新的宿主监测分析和小动物模型 通过核心服务中心单位在成本回收的基础上已经使用了十四年。 杜克大学 RBL 的一些设施、系统和关键核心研究设备已经过时或需要维修， 我们已经确定了该设施现有物理设施的六个关键缺陷。 限制生物安全或威胁其提供的服务和研究相关的基础设施 我们将在三个具体目标中解决这些缺陷：1) 实现建筑空气现代化。 控制系统 – 升级过时的 BSL3/ABSL3 楼宇控制系统、压力监视器和软件。 重新平衡、测试、验证和重新认证所有受影响的 BSL3/ABSL3 空间；2) 实现生物安全和安保现代化； 系统 - 更换 BSL2/BSL3/ABSL3 实验室中老化/损坏的生物安全柜。 BSL3 化学废水处理系统的组件 更换损坏或陈旧的闭路系统。 安全摄像头、布线以及与建筑安全控制系统的集成；以及 3) 现代化研究 资源 – 更换 BSL3 细胞中过时的高封闭细胞分选仪和定制 Bioprotect 罩 分类核心设施。升级阿伦敦生物防护鼠笼架上的鼓风机控制模块。 在 ABSL3 中，这些目标将由高度集成的项目管理团队来实现。 坚实的机构支持和值得信赖的承包商/供应商是原始设计和施工的一部分 设施的持续维护、维修和认证的一部分 过去14年。