Acquisition of Individually Ventilated Cage Rack Systems for the University of Mississippi Vivarium

为密西西比大学动物园采购独立通风的笼架系统

基本信息

批准号：
10533683
负责人：
Nicole M Ashpole
金额：
$ 28.1万
依托单位：
UNIVERSITY OF MISSISSIPPI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10533683
关键词：
Accreditation Address Air Air Movements Allergens Animal Experimentation Animal Housing Animal Husbandry Animal Technicians Animal Welfare Animals Area Biomedical Research Caliber Centers of Research Excellence Communities Environment Equipment Faculty Recruitment Feedback Filtration Floor Frequencies Funding Goals Growth Health Health Promotion Housing Humidity IACUC Individual Industry Standard Infrastructure Institution Knowledge Laboratories Laboratory Animal Production and Facilities Laboratory Research Mississippi Modernization Monitor Mus Occupational Safety Outcome Pharmacy Schools Rattus Reproducibility Research Research Activity Research Personnel Resistance Resources Risk Rodent Sum Surveys System Technology Temperature Time United States Office of Research Integrity Universities Work air filter animal care animal facility density evidence base exhaust high efficiency particulate air filter improved innovation pathogen prevent programs satisfaction social welfare

项目摘要

Project Summary Utilization of individually-ventilated cage systems (IVCs) for housing rodents has become the industry standard across the fields of biomedical research. The combined approach of socially housing rodents in filter-topped, microisolator cages with tightly-controlled air exchange rates and continuous monitoring of the homecage microenvironment promotes animal welfare, occupational safety, and research reproducibility. Ultimately, IVCs reduce animal husbandry burdens thereby encouraging efficient resource utilization and time allocation. At the University of Mississippi (UM), increased faculty recruitment and the recent growth of multiple animal research laboratories has resulted in a rising momentum to modernize our shared use animal facilities. Recent surveys of rodent research teams on campus revealed a robust demand for the incorporation of IVCs throughout the rodent vivarium facility. The goal of this proposal is to help meet the needs of animal research teams by implementing IVCs throughout the rodent housing rooms in our shared-use vivarium. The Vice Chancellor for Research, Office of Research Integrity and Compliance, and the Institutional Animal Care and Use Committee at UM gathered feedback from investigators, animal care staff, external consultants, and our accrediting bodies to assess areas for improvement and modernization throughout all animal housing areas on campus. Administrative units within the School of Pharmacy and Office of Research and Sponsored Programs recently supported the acquisition of 3 RAIR HD Super Mouse 750™ IVCs from LabProducts. The implementation of these systems was straightforward and subsequent benefits in microenvironment control and signs of animal and researcher satisfaction are clear. We now propose to implement the RAIR HD Super Mouse and Super Rat systems throughout all rodent housing rooms. Our facility is fully-equipped for immediate implementation, with no renovations required. The call for modernization is further driven by standing infrastructure concerns relating to the HVAC and potential allergen exposures within our facility, which the animal oversight teams responding to swiftly and strategically. Acquisition of the RAIR HD Super systems is a component of our strategic actions, as they have additional innovative air flow filtration technologies that can improve HVAC burden and allergen exposure. Thus, incorporation of IVCs in our rodent housing facility will allow us to remediate standing infrastructure concerns, prevent multiple potential issues, and promote efficiency within our animal research program.

项目概要利用独立通风笼系统 (IVC) 饲养啮齿类动物已成为生物医学研究领域的行业标准社会的综合方法。将啮齿动物安置在顶部有过滤器的微型隔离笼中，并严格控制空气交换率持续监测笼舍微环境可促进动物福利，最终，IVC 减少了畜牧业。负担，从而鼓励大学有效的资源利用和时间分配。密西西比州（UM）的教员增加了招聘，并且最近多种动物的生长研究实验室为我们的共享动物现代化带来了不断增长的势头最近对校园啮齿动物研究小组的调查显示，对设施的需求强劲。在整个啮齿动物饲养场设施中纳入 IVC 本提案的目标是。通过在整个过程中实施 IVC 来帮助满足动物研究团队的需求我们的共用饲养室中的啮齿动物饲养室。研究诚信和合规性以及机构动物护理和使用委员会 UM 收集了来自研究人员、动物护理人员、外部顾问和我们的反馈认可机构评估所有动物的改进和现代化领域校园内的行政单位和办公室。研究和赞助计划最近支持收购 3 RAIR HD Super 这些系统的实施是来自 LabProducts 的 Mouse 750™ IVC。微环境控制和动物和动物迹象方面的直接和后续效益研究人员的满意度是显而易见的，我们现在建议实施 RAIR HD 超级鼠标和我们的所有啮齿动物饲养室均配有超级老鼠系统，设施齐全。立即实施，无需翻修现代化的呼声进一步提高。由与暖通空调和潜在过敏原相关的长期基础设施问题驱动我们设施内的暴露情况，动物监督团队迅速做出了反应，战略性地收购 RAIR HD Super 系统是我们战略行动的一部分，因为他们拥有额外的创新气流过滤技术，可以减轻暖通空调的负担因此，将 IVC 纳入我们的啮齿动物饲养设施将使我们能够纠正长期存在的基础设施问题，防止多种潜在问题，并促进我们动物研究计划的效率。