Enhancement of Rat Housing at The Ohio State University

俄亥俄州立大学老鼠住房的改善

• 批准号: 8899121
• 负责人: Valerie K. Bergdall
• 金额: $ 49.91万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8899121
• 关键词: Accounting; Accreditation; Address; Age; Air; Animal Experimentation; Animal Welfare; Animals; Behavior Disorders; Behavioral; Biomedical Research; Brain; Capital Expenditures; Cardiovascular system; Communities; Development; Discipline; Equipment; Failure; Fetal Development; Floor; Functional disorder; Funding; Grant; Housing; Institution; International; Laboratory Animals; Metabolic; Modeling; Ohio; Physiological; Plumbing; Rattus; Reporting; Research; Research Personnel; Research Support; Rodent; Site Visit; United States National Institutes of Health; Universities; Water; animal care; expectation; guide for the care and use of laboratory animals; high efficiency particulate air filter; meetings; neurophysiology; social

 DESCRIPTION (provided by applicant): The Ohio State University (OSU) requests funding to purchase animal care equipment to enhance the conduct of biomedical research as well as increase regulatory compliance while optimizing animal welfare. Specifically, we are requesting $499,133 to purchase 18 Lab Products Super Rat MicroIsolator(r) 40 IVC racks with auto water, HEPA-filtered air supply units, complete cages with filter tops, and an additional 50% complete cages to provide sufficient supplies for routine cage changes. This project is intended to equip rodent housing rooms within an existing vivarium which already possesses the necessary plumbing and auto water, electrical, HVAC, cage wash, etc. capabilities without requiring any additional renovations, alterations, or fixed equipment. OSU is committed to upholding the NIH expectation regarding appropriate housing space while also accounting for the animals' social needs. It was noted on our most recent Association and Accreditation of Laboratory Animal Care International (AAALAC, Int.) site visit and the last two semi-annual Institutional Animal Care and Use inspection reports that large rats were individually housed at our facility. The recommended minimum space for rats in The Guide for the Care and Use of Laboratory Animals requires increased floor space with respect to animal size. However, our current rat caging requires that mature rats be housed individually to maintain compliance with Guide standards. The requested equipment will allow for increased floor space per cage, resulting in the ability to provide social housing of rats regardless of size. This is essential not only in ters of animal welfare, but also significantly impacts biomedical research support at our institution as it has been demonstrated that failure to meet animals' needs may result in abnormal brain development, physiologic dysfunction, and behavioral disorders. The requested equipment will benefit all investigators utilizing rat models at OSU. There are currently 59 researchers housing rats that have generated grants providing over $12,338,000 in direct research funding encompassing, but not limited to, cardiovascular, metabolic, fetal development, behavioral, and neurophysiological disciplines of study. The age and condition of current equipment in conjunction with the inability to provide optimal social housing due to size limitations to maintai regulatory compliance necessitates the need for this request. This proposal is also needed due to the inability to utilize capital expenditures for equipment purchases. This project is significat in addressing the strategic needs of our animal research community while aligning OSU's commitment to excellence in animal welfare.

 描述（由申请人提供）：俄亥俄州立大学 (OSU) 请求资金购买动物护理设备，以加强生物医学研究的进行并提高监管合规性，同时优化动物福利。具体来说，我们请求 499,133 美元购买 18 种实验室产品。 Super Rat MicroIsolator(r) 40 IVC 架，配有自动供水、HEPA 过滤空气供应装置、带过滤器顶部的完整笼子以及额外的 50% 完整笼子为日常笼子更换提供足够的供应 该项目旨在为现有动物园内的啮齿类动物饲养室配备设备，该动物园已经具备必要的管道和自动供水、电气、暖通空调、笼子清洗等功能，无需任何额外的翻新、改造、 OSU 致力于维护 NIH 对适当住房空间的期望，同时也考虑到动物的社会需求，这一点在我们最近的国际实验动物护理协会 (AAALAC, Int.) 现场访问和认证中得到了指出。这最近两次机构动物护理和使用检查报告表明，《实验动物护理和使用指南》中建议的大鼠最小空间需要根据动物大小增加占地面积。 ，我们目前的大鼠笼养要求将成熟的大鼠单独饲养，以保持符合指南标准，所要求的设备将允许增加每个笼子的占地面积，从而能够为大鼠提供社会住房，无论大小如何。就动物福利而言，也显着影响我们机构的生物医学研究支持 事实证明，不能满足动物的需求可能会导致大脑发育异常、生理功能障碍和行为障碍，所需的设备将使俄勒冈州立大学所有使用大鼠模型的研究人员受益，目前有 59 名饲养大鼠的研究人员获得了资助。超过 12,338,000 美元的直接研究经费，包括但不限于心血管、代谢、胎儿发育、行为和神经生理学学科的研究当前设备的年龄和状况以及由于规模而无法提供最佳的社会住房。由于无法利用资本支出购买设备，因此维持监管合规性的限制也需要该提案，该项目对于满足我们动物研究界的战略需求，同时协调俄勒冈州立大学对卓越的承诺具有重要意义。动物福利。