CORE-- NEUROPATHOLOGY

核心——神经病理学

• 批准号: 6616295
• 负责人: ELIZABETH J. COCHRAN
• 金额: $ 17.85万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6616295
• 关键词: Alzheimer's disease; Parkinson's disease; biomedical facility; brain; brain disorder diagnosis; brain imaging /visualization /scanning; computer data analysis; cryopreservation; histopathology; human tissue; immunocytochemistry; neuropathology; postmortem; tissue resource /registry

DESCRIPTION (provided by applicant): The major goal of the Neuropathology (NP) core of the Rush ADC is to provide investigators with well preserved brain tissue and complete diagnostic neuropathological evaluations from clinically well-characterized study participants. Provision of such tissue is necessary in order to fulfill the overall goal of the ADC to promote scientific investigations of Alzheimer's disease (AD). The specific aims of the NP Core are to: 1. Obtain brain tissue from clinically well-characterized elderly individuals with Alzheimer's disease, corresponding closely-matched control patients, and other neurological disease control cases through close collaboration with the Clinical and Religious Orders Study Cores; 2. Obtain the brain tissue with minimal postmortem intervals, preserved and processed in a standard and uniform fashion so that it can be used in various experimental protocols by a variety of investigators; 3. Perform a thorough and detailed neuropathological evaluation using standard, up-to-date, consistent diagnostic criteria for AD, Parkinson's disease (PD) and related disorders; 4. Reliably store and index the tissue and data, allowing for accurate and rapid information retrieval and tissue distribution to investigators. The ROS core is the source of clinical and pathological data and brain specimens which are especially valuable to investigators. It is composed of elderly Catholic clergy who volunteer to be neurologically and neuropsychologically examined each year, and consent to brain autopsy upon their death. The NP core has received, processed, preserved, and evaluated 130 brain autopsies from the subjects of the ROS core. Clinically, the group is composed of 37% with no cognitive impairment, 21% with mild cognitive impairment, and 42% with dementia. The NP core finds this brain tissue to be an extremely important resource for studies of both AD and aging-associated changes in the brain, as well as their inter-relationship.

描述（由申请人提供）： RUSH ADC的神经病理学（NP）核心的主要目标是提供 保存完好的脑组织和完整诊断的研究人员 临床表征良好的研究的神经病理学评估 参与者。为了履行该组织是必要的 ADC的总体目标是促进阿尔茨海默氏症的科学研究 疾病（AD）。 NP核心的具体目的是：1。获得脑组织 来自临床表征良好的老年人 疾病，相应匹配的对照患者和其他 神经疾病控制病例通过与 临床和宗教命令研究核心； 2。用 最小验尸间隔，以标准保留和处理 统一的时尚，以便可以在各种实验方案中使用 各种调查人员； 3。执行详尽而详细的神经病理学 使用标准的，最新的，一致的AD诊断标准进行评估， 帕金森氏病（PD）和相关疾病； 4。可靠的商店和索引 组织和数据，可以进行准确，快速的信息检索和 组织分布向研究者。 ROS核心是临床和病理数据和大脑的来源 对调查人员特别有价值的标本。它由 老年天主教神职人员自愿在神经方面和 每年都在神经心理学上检查，并同意脑尸检 他们的死。 NP核心已接收，处理，保存和评估 ROS核心受试者的130个大脑尸检。临床上，小组 由没有认知障碍的37％组成，有21％的认知能力 损害，痴呆症42％。 NP核心发现该脑组织是 用于研究AD和衰老相关的极其重要的资源 大脑的变化及其相互关系。