CORE-- NEUROPATHOLOGY

核心——神经病理学

• 批准号: 6098343
• 负责人: ELIZABETH J. COCHRAN
• 金额: $ 29.56万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-15 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6098343
• 关键词: Alzheimer's disease; Parkinson's disease; biomedical facility; brain; brain disorder diagnosis; brain imaging /visualization /scanning; computer data analysis; cryopreservation; histopathology; human tissue; immunocytochemistry; neuropathology; postmortem; tissue resource /registry

The major goal of the Neuropathology (NP) Core is to provide researchers with well characterized and preserved brain tissue and diagnostic neuropathology evaluations for Alzheimer's Disease (AD) patients and controls. Provision of such tissue is essential to the overall goal of the ADCC to promote strong scientific investigations of AD. In order to achieve this goal, the NP Core will carry out the following specific tasks: 1. obtain brain tissue from AD and control patients who have undergone multiple annual neuropsychological and neurological evaluations prior to death; 2. preserve the tissue in a variety of ways in order to allow application of the most up-to-date technologies by researchers; 3. apply standard criteria for the diagnosis of AD to these brains in a consistent fashion and provide a thorough neuropathological evaluation; 4. maintain an awareness of controversies and evolving standards in the diagnostic criteria; 3. store brain tissue and neuropathological data in a reliable way allowing rapid retrieval; and 6. encourage use of resources of the NP Core by researchers through tissue and data accessibility and accommodation of special preservation protocols. To improve access to well-studied control tissue, the ADCC has established the Religious Orders Study (ROS) Core. The NP Core has begun to obtain brain tissue (19 cases so far) from study subjects who have undergone careful neurological and neuropsychological follow-up. This tissue is likely to be especially valuable in making rigorous clinical- pathological correlations. The NP Core proposes to provide investigators with tissue from this a stereological quantitation of PHF-tau immunostained neuritic plaques and neurofibrillary tangles in the frontal, temporal, and parietal cortices, hippocampus, and entorhinal cortex of-tissue from the ROS core subjects, with the goals of further characterizing the interface between Alzheimer's disease and aging changes in the brain and evaluating stereologic technology as a potential tool to assist in diagnostic classification of this area.

神经病理学（NP）核心的主要目标是为研究人员提供 具有良好的特征和保存的脑组织和诊断 阿尔茨海默氏病（AD）患者的神经病理学评估和 控件。提供此类组织对于总体目标至关重要 ADCC旨在促进广泛的AD科学研究。为了 实现此目标，NP核心将执行以下特定 任务：1。从AD和对照患者中获取脑组织 经历了多个年度神经心理学和神经系统评估 死前； 2。以多种方式保留组织 允许研究人员应用最新技术； 3。 将标准标准应用于诊断为这些大脑的标准标准 一致的时尚并提供彻底的神经病理学评估； 4。保持对争议和不断发展的标准的认识 诊断标准； 3。将脑组织和神经病理学数据存储 一种可靠的方式，可以快速检索；和6。鼓励使用 研究人员通过组织和数据的资源 特殊保存方案的可访问性和适应性。 为了改善获得良好研究的控制组织的机会，ADCC具有 建立了宗教秩序研究（ROS）核心。 NP核心已经开始 从具有 经过了仔细的神经系统和神经心理学随访。这 组织对于制造严格的临床 - 可能特别有价值 - 病理相关性。 NP核心建议为调查人员提供 通过此组织的组织phf-tau的立体定量 免疫染色的神经斑块和神经原纤维缠结 额叶，颞叶和顶叶皮质，海马和内河 ROS核心主题的组织皮层，进一步的目标 表征阿尔茨海默氏病与衰老之间的界面 大脑的变化并评估立体技术作为潜力 协助该领域诊断分类的工具。