CORE--GENETICS

核心--遗传学

• 批准号: 6578733
• 负责人: HAYDEH PAYAMI
• 金额: $ 15.83万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578733
• 关键词: African American; Alzheimer's disease; Native Americans; Parkinson's disease; biomedical facility; case history; family genetics; genetic markers; genetic polymorphism; genetic registry /resource /referral center; genotype; histocompatibility typing; human genetic material tag; human old age (65+); human population genetics; human tissue; linkage mapping; tissue resource /registry

DESCRIPTION: (Adapted from the applicant's abstract) The essence of the overall OADC mission -- facilitation and advancement of research in Alzheimer disease (AD) and dementia -- will be achieved by the establishment of a new core, the "Genetics Core," organized to support current research strengths as well as respond to the developing potential of new discoveries in the field. The major themes of the research supported by the Genetics Core are: AD pathogenesis; healthy aging of the brain; Parkinson dementia; and gender and ethnic differences in AD and healthy aging. Within this context, the Genetics Core's specific aims are: (1) to provide continuously updated genetic information (i.e., documented family history, genotype, and banking of DNA and plasma) for the five key cohorts enrolled in the OADC, including AD patients, healthy elderly, Native-American elderly, African-American AD subjects, and Parkinson patients; (2) to bridge basic science and clinical research by providing basic scientists with a detailed genetic characterization of the OADC post-mortem tissue, DNA samples from OADC subjects, and facilities and expertise to test for genetic linkage and association between AD and their molecules of interest (CNTF, CNTF receptor, acidic and basic FGF, FGF receptors 1-4, K+ channels, and others in the future); (3) to support ongoing collaborative genetic studies with the Seattle and the UCLA ADC's including genetic linkage studies of familial AD kindreds, examining the effects of HLA, ApoE, and gender on the age at onset of AD; (4) to collaborate with the OHSU Clinical Genetics Program and the OHSU DNA Diagnostic Laboratory to provide genetic counseling and risk assessment to the public; and (5) to participate in educational programs of the Education and Information Transfer Core and of the Alzheimer Association. The collaborations outlined above are funded independently. The contributions of the OADC Genetics Core to the collaborative research projects will be documented family histories, genotypes, and DNA and plasma from OADC subjects. Similarly, the public service programs for genetic counseling and testing will be financially independent of the OADC but will have close scientific ties with OADC investigators.

描述：（改编自申请人的摘要） OADC的总体任务 - 促进和进步研究 阿尔茨海默氏病（AD）和痴呆 - 将通过 建立新的核心，即“遗传学核心”，以支持 当前的研究优势以及对发展的回应 该领域新发现的潜力。主要主题 遗传学核心支持的研究是：AD发病机理；健康 大脑衰老；帕金森痴呆症；性别和种族 广告和健康衰老的差异。在这种情况下，遗传学 Core的具体目的是：（1）提供不断更新的遗传 信息（即记录的家族史，基因型和银行业务 DNA和等离子体）用于在OADC中注册的五个关键人群，包括 广告患者，健康的老年人，美国土著老年人，非裔美国人 广告主题和帕金森患者； （2）桥接基础科学和 通过为基础科学家提供详细的遗传学的临床研究 OADC验尸组织的表征，来自OADC的DNA样品 主题，设施和专业知识，以测试遗传联系和 AD与他们感兴趣的分子之间的关联（CNTF，CNTF 受体，酸性和碱性FGF，FGF受体1-4，K+通道以及 将来其他人）； （3）支持正在进行的协作遗传 西雅图和UCLA ADC的研究包括遗传联系 对家族性广告的研究，研究了HLA，APOE和 广告发作时的性别； （4）与OHSU合作 临床遗传学计划和OHSU DNA诊断实验室 向公众提供遗传咨询和风险评估； （5） 参加教育和信息的教育计划 转移核心和阿尔茨海默氏症协会。 上面概述的合作是独立资助的。这 OADC遗传学核心对合作研究的贡献 项目将被记录在家庭历史，基因型和DNA以及 来自OADC受试者的血浆。同样，公共服务计划 遗传咨询和测试将在财务上独立于 OADC，但将与OADC调查人员有密切的科学联系。