CORE--GENETICS

核心--遗传学

• 批准号: 6295488
• 负责人: HAYDEH PAYAMI
• 金额: $ 18.31万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6295488
• 关键词: African American; Alzheimer's disease; Native Americans; Parkinson's disease; biomedical facility; case history; family genetics; genetic markers; genetic polymorphism; genetic registry /resource /referral center; genotype; histocompatibility typing; human genetic material tag; human old age (65+); human population genetics; human tissue; linkage mapping; tissue resource /registry

DESCRIPTION: (Adapted from the applicant's abstract) The essence of the overall OADC mission -- facilitation and advancement of research in Alzheimer disease (AD) and dementia -- will be achieved by the establishment of a new core, the "Genetics Core," organized to support current research strengths as well as respond to the developing potential of new discoveries in the field. The major themes of the research supported by the Genetics Core are: AD pathogenesis; healthy aging of the brain; Parkinson dementia; and gender and ethnic differences in AD and healthy aging. Within this context, the Genetics Core's specific aims are: (1) to provide continuously updated genetic information (i.e., documented family history, genotype, and banking of DNA and plasma) for the five key cohorts enrolled in the OADC, including AD patients, healthy elderly, Native-American elderly, African-American AD subjects, and Parkinson patients; (2) to bridge basic science and clinical research by providing basic scientists with a detailed genetic characterization of the OADC post-mortem tissue, DNA samples from OADC subjects, and facilities and expertise to test for genetic linkage and association between AD and their molecules of interest (CNTF, CNTF receptor, acidic and basic FGF, FGF receptors 1-4, K+ channels, and others in the future); (3) to support ongoing collaborative genetic studies with the Seattle and the UCLA ADC's including genetic linkage studies of familial AD kindreds, examining the effects of HLA, ApoE, and gender on the age at onset of AD; (4) to collaborate with the OHSU Clinical Genetics Program and the OHSU DNA Diagnostic Laboratory to provide genetic counseling and risk assessment to the public; and (5) to participate in educational programs of the Education and Information Transfer Core and of the Alzheimer Association. The collaborations outlined above are funded independently. The contributions of the OADC Genetics Core to the collaborative research projects will be documented family histories, genotypes, and DNA and plasma from OADC subjects. Similarly, the public service programs for genetic counseling and testing will be financially independent of the OADC but will have close scientific ties with OADC investigators.

描述：（改编自申请人的摘要） OADC 的总体使命——促进和推进以下方面的研究 阿尔茨海默病（AD）和痴呆——将通过 建立一个新的核心，即“遗传学核心”，组织起来支持 当前的研究优势以及对发展中的反应 该领域新发现的潜力。会议的主要主题 遗传学核心支持的研究有： AD 发病机制；健康 大脑老化；帕金森痴呆症；以及性别和种族 AD 和健康老龄化的差异。在此背景下，遗传学 Core的具体目标是：（1）提供不断更新的基因 信息（即记录的家族史、基因型和银行信息） DNA 和血浆）用于 OADC 登记的五个关键人群，包括 AD 患者、健康老年人、美国原住民老年人、非洲裔美国人 AD 受试者和帕金森患者； (2) 架起基础科学与 为基础科学家提供详细的遗传信息进行临床研究 OADC 死后组织、OADC DNA 样本的表征 测试遗传连锁的科目、设施和专业知识 AD 与其感兴趣的分子（CNTF、CNTF 受体、酸性和碱性 FGF、FGF 受体 1-4、K+ 通道和 未来的其他人）； (3) 支持正在进行的协作遗传 与西雅图和加州大学洛杉矶分校 ADC 进行的研究，包括遗传关联 对家族性 AD 亲属的研究，检查 HLA、ApoE 和 性别对 AD 发病年龄的影响； (4) 与OHSU合作 临床遗传学计划和 OHSU DNA 诊断实验室 向公众提供遗传咨询和风险评估；和（5） 参加教育和信息部的教育计划 转移核心和阿尔茨海默病协会。 上述合作是独立资助的。这 OADC 遗传学核心对合作研究的贡献 项目将记录家族史、基因型和 DNA， 来自 OADC 受试者的血浆。同样，公共服务计划 遗传咨询和检测将在财务上独立于 OADC 但将与 OADC 研究人员保持密切的科学联系。