An Irish Affected Sib Pair Study of Alcohol Dependence

爱尔兰受影响同胞对酒精依赖的研究

• 批准号: 6478226
• 负责人: Carol Arlene Prescott
• 金额: $ 93.84万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478226
• 关键词: British Isles; United States; alcoholism /alcohol abuse; behavioral /social science research tag; case history; caucasian American; family genetics; genetic markers; genetic susceptibility; genotype; human genetic material tag; human subject; interview; linkage disequilibriums; linkage mapping; mental health epidemiology; molecular genetics; patient oriented research; phenotype; racial /ethnic difference; siblings

DESCRIPTION (provided by applicant): The goal of this project is to detect the genomic location of susceptibility loci (SL) for alcoholism. Alcoholism is a chronic, progressive disorder that takes an enormous toll on health, social functioning and economic productivity, and threatens the lives of drinkers and others. The available literature provides strong evidence that genes are involved in the vulnerability to develop alcoholism. Identifying the location of these genes is the first step toward understanding their mechanism of action and developing more effective treatments. This application is for a competitive renewal to fund the genotyping and linkage analyses of the data collected under R01-AAI 1408. The first phase of the study funded the ascertainment, clinical assessment and DNA collection in Ireland of pairs of adult siblings affected with DSM-IV alcohol dependence, as well as a brief assessment and DNA collection from their parents. The specific aims of this proposal are: I )To conduct a genome scan of a sample of 600 pairs of siblings affected with alcohol dependence; 2) To perform statistical linkage analyses of the genome scan data, using multiple phenotypes as outcomes to identify regions which may contain SL; and 3) To attempt to identify SL more precisely by following up the linkage results by identifying narrower subregions using linkage analysis, using pilot fine-scale mapping to narrow the sub-regions, based on association methods, and testing for replication in an independent sample for which high-quality clinical interview data and DNA are already available. To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics.

描述（由申请人提供）：该项目的目的是检测 酒精中毒易感基因座（SL）的基因组位置。酒精中毒是一个 慢性，进行性疾病，对健康，社会造成巨大损失 运作和经济生产力，威胁饮酒者的生命和 其他的。可用文献提供了有力的证据，表明基因是 参与发展酗酒的脆弱性。识别位置 这些基因是理解其作用机理的第一步 并开发更有效的治疗方法。 该应用程序是为了竞争性的续约，以资助基因分型和 R01-AAI 1408收集的数据的链接分析。 该研究资助了确定性，临床评估和DNA收集 爱尔兰的成对成年兄弟姐妹受到DSM-IV依赖性影响的爱尔兰 以及父母的简短评估和DNA收集。 该提案的具体目的是：i）进行样品的基因组扫描 受酒精依赖影响的600对兄弟姐妹； 2）执行 使用多种表型对基因组扫描数据的统计连锁分析 作为确定可能包含SL的区域的结果； 3）试图 通过识别识别链接结果，可以更准确地识别SL 使用链接分析的较窄的子区域，使用飞行员细尺度映射到 根据关联方法范围缩小子区域的范围，并测试 在独立样本中复制高质量临床访谈 数据和DNA已经可用。为了进行这个项目，我们组装了 临床评估，统计遗传学和分子专家团队 遗传学。