An Irish Affected Sib Pair Study of Alcohol Dependence

爱尔兰受影响同胞对酒精依赖的研究

基本信息

批准号：
6945943
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 38.72万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-25 至 2007-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to detect the genomic location of susceptibility loci (SL) for alcoholism. Alcoholism is a chronic, progressive disorder that takes an enormous toll on health, social functioning and economic productivity, and threatens the lives of drinkers and others. The available literature provides strong evidence that genes are involved in the vulnerability to develop alcoholism. Identifying the location of these genes is the first step toward understanding their mechanism of action and developing more effective treatments. This application is for a competitive renewal to fund the genotyping and linkage analyses of the data collected under R01-AAI 1408. The first phase of the study funded the ascertainment, clinical assessment and DNA collection in Ireland of pairs of adult siblings affected with DSM-IV alcohol dependence, as well as a brief assessment and DNA collection from their parents. The specific aims of this proposal are: I )To conduct a genome scan of a sample of 600 pairs of siblings affected with alcohol dependence; 2) To perform statistical linkage analyses of the genome scan data, using multiple phenotypes as outcomes to identify regions which may contain SL; and 3) To attempt to identify SL more precisely by following up the linkage results by identifying narrower subregions using linkage analysis, using pilot fine-scale mapping to narrow the sub-regions, based on association methods, and testing for replication in an independent sample for which high-quality clinical interview data and DNA are already available. To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics.

描述（由申请人提供）：该项目的目的是检测酒精中毒易感基因座（SL）的基因组位置。酒精中毒是一个慢性，进行性疾病，对健康，社会造成巨大损失运作和经济生产力，威胁饮酒者的生命和其他的。可用文献提供了有力的证据，表明基因是参与发展酗酒的脆弱性。识别位置这些基因是理解其作用机理的第一步并开发更有效的治疗方法。该应用程序是为了竞争性的续约，以资助基因分型和 R01-AAI 1408收集的数据的链接分析。该研究资助了确定性，临床评估和DNA收集爱尔兰的成对成年兄弟姐妹受到DSM-IV依赖性影响的爱尔兰以及父母的简短评估和DNA收集。该提案的具体目的是：i）进行样品的基因组扫描受酒精依赖影响的600对兄弟姐妹； 2）执行使用多种表型对基因组扫描数据的统计连锁分析作为确定可能包含SL的区域的结果； 3）试图通过识别识别链接结果，可以更准确地识别SL 使用链接分析的较窄的子区域，使用飞行员细尺度映射到根据关联方法范围缩小子区域的范围，并测试在独立样本中复制高质量临床访谈数据和DNA已经可用。为了进行这个项目，我们组装了临床评估，统计遗传学和分子专家团队遗传学。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies.

DOI：
10.1017/s0033291714002165
发表时间：
2015-04
期刊：
PSYCHOLOGICAL MEDICINE
影响因子：
6.9
作者：
Verhulst, B.;Neale, M. C.;Kendler, K. S.
通讯作者：
Kendler, K. S.

Genome-wide linkage scans for major depression in individuals with alcohol dependence.

DOI：
10.1016/j.jpsychires.2009.12.005
发表时间：
2010-07
期刊：
Journal of psychiatric research
影响因子：
4.8
作者：
Kuo PH;Neale MC;Walsh D;Patterson DG;Riley B;Prescott CA;Kendler KS
通讯作者：
Kendler KS

A multivariate twin study of the DSM-IV criteria for antisocial personality disorder.

DOI：
10.1016/j.biopsych.2011.05.019
发表时间：
2012-02-01
期刊：
BIOLOGICAL PSYCHIATRY
影响因子：
10.6
作者：
Kendler, Kenneth S.;Aggen, Steven H.;Patrick, Christopher J.
通讯作者：
Patrick, Christopher J.

ERGR: An ethanol-related gene resource.

DOI：
10.1093/nar/gkn816
发表时间：
2009-01
期刊：
Nucleic acids research
影响因子：
14.9
作者：
Guo AY;Webb BT;Miles MF;Zimmerman MP;Kendler KS;Zhao Z
通讯作者：
Zhao Z

Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.

DOI：
10.1007/s10519-011-9488-8
发表时间：
2012-01
期刊：
BEHAVIOR GENETICS
影响因子：
2.6
作者：
van Beek, Jenny H. D. A.;Kendler, Kenneth S.;de Moor, Marleen H. M.;Geels, Lot M.;Bartels, Meike;Vink, Jacqueline M.;van den Berg, Stephanie M.;Willemsen, Gonneke;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.