Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

吸毒障碍的遗传、社会和发育流行病学

基本信息

批准号：
9893984
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 9.84万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9893984
关键词：
Achievement Adolescence Adult Age Birth Blood Coagulation Factor VII Characteristics Child Collaborations Communities Country Crime Data Data Sources Developed Countries Developing Countries Development Disease Distal Drug Modelings Drug Use Disorder Drug abuse Employment Environment Environmental Risk Factor Epidemiology Equation Etiology Evaluation Female Funding Gender Generations Genes Genetic Genetic Risk Geographic Information Systems Goals Household Immigrant Immigration Intuition Joints Low income Marriage Measures Mediating Medical Mental disorders Methods Military Personnel Minority Modeling Nature Nurse Midwives Parents Partner Abuse Pathway interactions Personality Pharmaceutical Preparations Pharmacoepidemiology Phase Phenotype Policies Population Premature Mortality Prevalence Prevention Productivity Recurrence Registries Reporting Research Resources Risk Risk Factors Role Sampling Schools Sex Differences Siblings Smoking Smoking Status Source Specific qualifier value Specificity Spouses Statistical Methods Stepparent Structure Sweden Syndrome Twin Multiple Birth Universities Virginia Woman age difference alcohol use disorder base causal model cognitive ability convict criminal behavior design deviant disability disorder risk genetic epidemiology innovation male men middle age migration offspring peer predictive test programs psychologic segregation sex social

项目摘要

Project Summary This revision of a competitive renewal seeks to continue our innovative and highly productive research program which has the goal of understanding the etiology, consequences and causes of desistance of drug use disorders (DUD) utilizing data available on the entire population of Sweden of unparalleled completeness and depth. We have eight specific aims which focus on the etiology and course and consequences of DUD. These aims are: i) to develop a structural equation (SEM) based approach to co-relative analyses and then apply it to critical risk factors for DUD available in Sweden, permitting a more rigorous assessment than hitherto possible of the degree to which risk factor-DUD associations are due to familial confounding versus causal effects; ii) to examine how strongly DUD is predicted by measures of IQ and personality at age 18 available on ~ 97% of all Swedish males born 1951-1975 and to clarify the degree to which these associations are likely causal; iii) to explore the similarity and differences in risk factors for DUD and smoking in over 1.2 million fertile women for whom smoking status is available as part of nurse-midwife's reports; iv) to explore how factors related to immigration, with a focus on macro-level contextual characteristics (i.e., residential segregation), impact risk for DUD among first and second generation immigrants to Sweden using analytical Geographic Information Systems (GIS) methods; v) to clarify how risk factors for DUD vary by gender using discordant opposite-sex relative pairs and the degree to which these risk factors are specific to DUD versus shared with other key externalizing syndromes of alcohol use disorders and crime; vi) to develop a comprehensive SEM for DUD in adoptees, twins, siblings, half-siblings, and typical, not-lived-with and step- parents that will permit joint estimation of four sources of familial-environmental effects, to examine developmental dynamics in the genetic and environmental risk factors for DUD from adolescence to middle age utilizing a longitudinal twin-sibling design and to clarify key mediating mechanisms from distal to more proximal risk factors by constructing a phenotypic-developmental SEM model for DUD that incorporates a wide array of genetic and environmental risk factors; vii) to develop longitudinal models to clarify the social, psychiatric and medical consequences of DUD using co-relative designs to control for familial confounding and viii) to explore the predictors of desistance from DUD on both the latent and specified risk factor level and clarify the causal nature of these associations via co-relative designs. We will use comprehensive data from multiple nationwide data sources in Sweden on 11.8 million men and women to accomplish these goals. Applying the deep expertise of our research groups at Virginia Commonwealth and Lund University in drug abuse research, social and genetic epidemiology and causal modeling to a uniquely powerful sample, we expect this study to have important implications for DUD research, prevention and policy.

项目概要此次竞争性更新的修订旨在继续我们的创新和高产研究旨在了解戒毒的病因、后果和原因的计划使用障碍 (DUD) 利用瑞典全体人口的可用数据，其完整性无与伦比和深度。我们有八个具体目标，重点关注 DUD 的病因、病程和后果。这些目标是： i) 开发基于结构方程 (SEM) 的关联分析方法，然后将其应用于瑞典 DUD 的关键风险因素，从而可以进行比迄今为止，风险因素与 DUD 关联在多大程度上可能是由于家族混杂因素与因果效应； ii) 检查 18 岁时通过智商和性格测量来预测 DUD 的程度 1951 年至 1975 年出生的所有瑞典男性中约有 97% 都存在这种情况，并阐明了这些关联的程度可能是因果关系； iii) 探讨1.2以上人群DUD和吸烟危险因素的相似性和差异数以百万计的生育妇女的吸烟状况可作为护士/助产士报告的一部分获得； iv) 探索如何与移民相关的因素，重点关注宏观层面的背景特征（即居住地隔离），使用分析方法对瑞典第一代和第二代移民 DUD 的影响风险地理信息系统（GIS）方法； v) 阐明 DUD 的风险因素如何因性别而异不一致的异性相对配对以及这些风险因素对 DUD 的特有程度与酒精使用障碍和犯罪的其他主要外化综合症相同； vi) 开发一个对收养者、双胞胎、兄弟姐妹、同父异母兄弟姐妹以及典型的、非同居者和继父母的 DUD 进行全面的 SEM 允许联合评估家庭环境影响的四个来源的父母，以检查从青春期到中期 DUD 的遗传和环境危险因素的发展动态年龄利用纵向双胞胎设计，并阐明从远端到更远端的关键中介机制通过构建 DUD 的表型发育 SEM 模型来确定近端危险因素，该模型包含广泛的一系列遗传和环境风险因素； vii) 开发纵向模型来阐明社会、使用相关设计来控制家族混杂因素和 DUD 的精神和医学后果 viii) 探索在潜在和特定风险因素水平上停止 DUD 的预测因素，以及通过相关设计阐明这些关联的因果性质。我们将使用来自的综合数据瑞典多个全国性数据源涉及 1180 万名男性和女性实现这些目标的情况。应用弗吉尼亚联邦和隆德大学研究小组在药物方面的深厚专业知识我们通过滥用研究、社会和遗传流行病学以及因果建模来建立一个独特的强大样本预计这项研究将对 DUD 研究、预防和政策产生重要影响。