Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

吸毒障碍的遗传、社会和发育流行病学

基本信息

批准号：
9893984
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 9.84万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9893984
关键词：
Achievement Adolescence Adult Age Birth Blood Coagulation Factor VII Characteristics Child Collaborations Communities Country Crime Data Data Sources Developed Countries Developing Countries Development Disease Distal Drug Modelings Drug Use Disorder Drug abuse Employment Environment Environmental Risk Factor Epidemiology Equation Etiology Evaluation Female Funding Gender Generations Genes Genetic Genetic Risk Geographic Information Systems Goals Household Immigrant Immigration Intuition Joints Low income Marriage Measures Mediating Medical Mental disorders Methods Military Personnel Minority Modeling Nature Nurse Midwives Parents Partner Abuse Pathway interactions Personality Pharmaceutical Preparations Pharmacoepidemiology Phase Phenotype Policies Population Premature Mortality Prevalence Prevention Productivity Recurrence Registries Reporting Research Resources Risk Risk Factors Role Sampling Schools Sex Differences Siblings Smoking Smoking Status Source Specific qualifier value Specificity Spouses Statistical Methods Stepparent Structure Sweden Syndrome Twin Multiple Birth Universities Virginia Woman age difference alcohol use disorder base causal model cognitive ability convict criminal behavior design deviant disability disorder risk genetic epidemiology innovation male men middle age migration offspring peer predictive test programs psychologic segregation sex social

项目摘要

Project Summary This revision of a competitive renewal seeks to continue our innovative and highly productive research program which has the goal of understanding the etiology, consequences and causes of desistance of drug use disorders (DUD) utilizing data available on the entire population of Sweden of unparalleled completeness and depth. We have eight specific aims which focus on the etiology and course and consequences of DUD. These aims are: i) to develop a structural equation (SEM) based approach to co-relative analyses and then apply it to critical risk factors for DUD available in Sweden, permitting a more rigorous assessment than hitherto possible of the degree to which risk factor-DUD associations are due to familial confounding versus causal effects; ii) to examine how strongly DUD is predicted by measures of IQ and personality at age 18 available on ~ 97% of all Swedish males born 1951-1975 and to clarify the degree to which these associations are likely causal; iii) to explore the similarity and differences in risk factors for DUD and smoking in over 1.2 million fertile women for whom smoking status is available as part of nurse-midwife's reports; iv) to explore how factors related to immigration, with a focus on macro-level contextual characteristics (i.e., residential segregation), impact risk for DUD among first and second generation immigrants to Sweden using analytical Geographic Information Systems (GIS) methods; v) to clarify how risk factors for DUD vary by gender using discordant opposite-sex relative pairs and the degree to which these risk factors are specific to DUD versus shared with other key externalizing syndromes of alcohol use disorders and crime; vi) to develop a comprehensive SEM for DUD in adoptees, twins, siblings, half-siblings, and typical, not-lived-with and step- parents that will permit joint estimation of four sources of familial-environmental effects, to examine developmental dynamics in the genetic and environmental risk factors for DUD from adolescence to middle age utilizing a longitudinal twin-sibling design and to clarify key mediating mechanisms from distal to more proximal risk factors by constructing a phenotypic-developmental SEM model for DUD that incorporates a wide array of genetic and environmental risk factors; vii) to develop longitudinal models to clarify the social, psychiatric and medical consequences of DUD using co-relative designs to control for familial confounding and viii) to explore the predictors of desistance from DUD on both the latent and specified risk factor level and clarify the causal nature of these associations via co-relative designs. We will use comprehensive data from multiple nationwide data sources in Sweden on 11.8 million men and women to accomplish these goals. Applying the deep expertise of our research groups at Virginia Commonwealth and Lund University in drug abuse research, social and genetic epidemiology and causal modeling to a uniquely powerful sample, we expect this study to have important implications for DUD research, prevention and policy.

项目摘要对竞争性更新的这种修订旨在继续我们的创新和高产的研究计划的目标是了解毒品的病因，后果和原因使用无与伦比完整性的瑞典人口中可用的数据使用障碍（DUD）和深度。我们有八个具体目标，这些目标集中在DUD的病因和过程和后果上。这些目的是：i）开发一种基于结构方程（SEM）的方法来共同分析，然后将其应用于瑞典可用的DUD的关键风险因素，允许更严格的评估迄今为止可能是由于家族混乱而导致的风险因素与因果影响； ii）检查18岁时智商和个性的措施来预测如何强烈地预测在1951年至1975年出生的所有瑞典男性中，有97％可用，并阐明这些关联的程度可能是因果； iii）探索超过1.2的DUD和吸烟的危险因素的相似性和差异作为同会妇女报告的一部分，有数百万名肥沃的妇女为他们提供吸烟状况； iv）探索如何与移民有关的因素，重点是宏观上下文特征（即住宅种族隔离），使用分析的第一代移民和第二代移民的影响风险地理信息系统（GIS）方法； v）阐明使用性别的风险因素如何因性别而异不一致的异性相对对以及这些风险因素特定于dud的程度与其他关键的酒精使用障碍和犯罪综合症共享； vi）开发一个在收养者，双胞胎，兄弟姐妹，半兄弟姐妹以及典型的，不生活和步骤的综合SEM中父母将允许共同估算四个家族环境影响的来源，可以检查从青春期到中间的DUD的遗传和环境风险因素的发育动力学使用纵向双胞胎兄弟设计的年龄，并阐明从远端到更多的关键中介机制通过为DUD构建表型开发的SEM模型，近端风险因素一系列遗传和环境风险因素； vii）开发纵向模型以阐明社会， DUD使用共同设计的精神病和医学后果来控制家庭混淆和 viii）探索对潜在和指定危险因素水平和指定危险因素水平和通过共生设计阐明这些关联的因果性质。我们将使用来自瑞典的多个全国性数据来源以1,180万男女实现这些目标。在弗吉尼亚联邦和隆德大学应用我们的研究小组的深厚专业知识滥用研究，社会和遗传流行病学以及为独特的样本建模，我们期望这项研究对DUD研究，预防和政策具有重要意义。