MEDIATION AND MODERATION OF GENETIC RISK FOR ALCOHOLISM

调节和减轻酗酒的遗传风险

• 批准号: 6497144
• 负责人: Carol Arlene Prescott
• 金额: $ 9.71万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6497144
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; behavioral genetics; clinical research; comorbidity; disease /disorder etiology; disease /disorder proneness /risk; human subject; mathematical model; mental health epidemiology; model design /development; twin /multiplet

The candidate is applying for a mentored research scientist development award. Kenneth Kendler, M.D., a world-renowned researcher in the genetic epidemiology of psychiatric disorders, will be her primary preceptor. The training setting in the Virginia Institute for Psychiatric and Behavioral Genetics, a multidisciplinary institute located in the Medical College of Virginia/Virginia Commonwealth University. Research conducted during the past decade has implicated genetic factors in alcohol use, abuse and dependence. An important focus of research in the next decade will be to understand the mechanisms by which these influences operate. The overall goal of the proposed research is to identify mechanisms for transmission of vulnerability to alcohol use and alcoholism. Specific aims include: studying genetic contributions to lifetime risk for alcohol use, abuse and dependence, as well as changes in alcohol consumption and symptomatology; investigating the basis for the association between alcohol-related behaviors and a variety of proposed "risk factors"; studying the basis of the co-occurrence of alcoholism and a variety of other forms of psychopathology; and identifying the role of personality traits and comorbid psychopathology as potential mediators and moderators of genetic vulnerability. To accomplish these goals, the candidate will obtain training in advanced statistical methods and apply them to data collected from personal interviews with over 9,000 twins and their parents ascertained through the population-based Virginia Twin Registry. The candidate's future career goal is to develop comprehensive etiological models for alcohol use and alcoholism by combining behavior genetic designs with behavioral pharmacology paradigms and molecular genetic data. To facilitate this, the candidate will obtain training in behavioral pharmacology and molecular genetics.

候选人正在申请指导的研究科学家发展 奖。 肯尼思·肯德勒（Kenneth Kendler），医学博士，世界知名的研究员 精神疾病的遗传流行病学将是她的主要 主持人。 弗吉尼亚研究所的培训设置 精神病和行为遗传学，多学科研究所 位于弗吉尼亚/弗吉尼亚州医学院 大学。 过去十年进行的研究暗示了遗传因素 在饮酒，滥用和依赖中。 研究的重要重点 在接下来的十年中，将是了解这些机制 影响运作。 拟议研究的总体目标是 确定传播酒精使用脆弱性的机制 酗酒。具体目的包括：研究遗传贡献 终身饮酒，滥用和依赖的风险以及变化 在饮酒和症状学中；调查基础 与酒精相关的行为与各种各样的关联 拟议的“风险因素”；研究共同发生的基础 酒精中毒和各种其他形式的心理病理学；和 确定人格特质和合并症的心理病理学的作用 作为遗传脆弱性的潜在介体和主持人。 到 实现这些目标，候选人将获得高级培训 统计方法并将其应用于从个人的数据中收集的数据 与9,000多个双胞胎及其父母的采访确定了 基于人群的弗吉尼亚双人注册表。 候选人的未来职业目标是发展全面 通过合并行为的饮酒和酒精中毒模型 具有行为药理学范式和分子的遗传设计 遗传数据。 为了促进这一点，候选人将获得培训 在行为药理学和分子遗传学中。