Functional Neuroanatomical Deficits in ADHD Families

ADHD 家族的功能性神经解剖学缺陷

• 批准号: 6469438
• 负责人: STEPHEN HINSHAW
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-11 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6469438
• 关键词: adolescence (12-20); adult human (21+); attention deficit disorder; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; brain morphology; central nervous system stimulants; clinical research; disease /disorder etiology; family genetics; functional magnetic resonance imaging; human subject; magnetic resonance imaging; methylphenidate; morphometry; neuroanatomy; neuropharmacology; neuropsychological tests; neuropsychology; parents; patient oriented research; psychobiology; psychopharmacology

DESCRIPTION (provided by applicant): Despite a plethora of neuropsychological and family-based research suggesting that Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiologically-based disorder, studies attempting to define the neurobiological nature of ADHD have been few. As stated in the NIMH Consensus Development Conference on ADHD, there is a clear need to more basically define ADHD using basic research techniques. The proposed study will utilize the Multimodal Treatment Study of ADHD children (MTA) sample to recruit 30 ADHD parent-child dyads. ADHD dyads will consist of ADHD children and their concordantly-affected ADHD parents. Fifteen normal dyads will also be recruited who do not meet ADHD diagnostic criteria. Volumetric images using Magnetic Resonance Imaging (MRI) will be acquired on all dyads. In addition, all dyads will perform a series of neuropsychological tests while generic brain activation is assessed using functional MRI (fMRI). ADHD parent-child dyads will also participate in a repeated measures study examining functional neuroanatomical change in response to stimulant medication. Brain activation volumes and magnitudes in pre-specified regions of interest will be assessed. Between-group comparisons will evaluate structural and functional neuroanatomical differences between ADHD and normal parent-child dyads. Within-group analyses will compare ADHD patients' functional activation changes across placebo and active medication conditions. In addition, parent-child correspondences in neuropsychological performance, neuroanatomy, and brain activation will be examined within the two groups of dyads. This application is a collaborative R01 that will involve five sites. Participants will be recruited from three MTA sites: University Medical Center (DUMC), New York State Psychiatric Institute, and UC Berkeley. Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively.

描述（由申请人提供）：尽管有很多神经心理学 基于家庭的研究表明注意力缺陷多动症 疾病（ADHD）是一种基于神经生物学的疾病，试图研究 定义多动症的神经生物学性质很少。如NIMH中所述 关于多动症的共识开发会议，显然需要更多 基本上使用基础研究技术定义ADHD。拟议的研究将 利用ADHD儿童（MTA）样品的多模式治疗研究招募 30个ADHD亲子二元组。多动症二元组将由多动症儿童及其 一致影响的多动症父母。也将招募15个普通二元组 谁不符合多动症诊断标准。使用磁性图像 共振成像（MRI）将在所有二元组上获取。此外，所有二元组 将进行一系列神经心理学测试，而通用大脑 使用功能性MRI（fMRI）评估激活。 ADHD亲子二元组 还将参与重复的措施研究检查功能 响应刺激性药物的神经解剖学变化。大脑激活 将评估预先指定的感兴趣区域的量和大小。 组间比较将评估结构和功能 多动症与正常亲子二元组之间的神经解剖学差异。 组内分析将比较ADHD患者的功能激活变化 跨安慰剂和主动用药条件。另外，父母 神经心理学表现，神经解剖学和大脑的对应关系 将在两组二元组中检查激活。此应用程序是 协作R01将涉及五个站点。参与者会 从三个MTA站点招募：纽约大学医学中心（DUMC） 国家精神病学院和加州大学伯克利分校。成像将在 康奈尔州威尔医学院DUMC的相应成像网站 大学和斯坦福大学。