FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION DEFICIT H

注意力缺陷儿童多模式治疗研究的随访 H

• 批准号: 8248676
• 负责人: STEPHEN HINSHAW
• 金额: $ 51.73万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-13 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8248676
• 关键词: Accidents; Achievement; Address; Alcohol or Other Drugs use; Amphetamines; Anxiety; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral Symptoms; Blood Pressure; Child; Child Rearing; Combined Modality Therapy; Communities; Comorbidity; Contracts; Control Groups; Data Collection; Disease; Dose; Eating Disorders; Educational Status; Effectiveness; Exposure to; Goals; Grant; Growth; Health; Heart Rate; Height; Incidence; Independent Living; Individual; Long-Term Effects; Mediation; Mediator of activation protein; Medical; Medication Management; Mental Depression; Mental Health; Mental disorders; Modality; National Institute of Mental Health; Occupational; Outcome; Participant; Pharmaceutical Preparations; Phase; Psychopathology; Psychotic Mood Disorders; Puberty; Randomized; Relative (related person); Research; Research Design; Research Personnel; Risk; Schools; Services; Site; Speed; Substance Addiction; Substance abuse problem; Support Contracts; Symptoms; Tic disorder; Time; U-Series Cooperative Agreements; adverse outcome; clinical research site; design; follow-up; psychosocial; psychotic mania; social; standard care; suicidal behavior; treatment as usual; treatment site

The purpose of this contract is to study the long-term effects of different treatment modalities for children with attention deficit hyperactivity disorder (ADHD) through a systematic follow-up of the subjects who participated in the Multimodal Treatment Study of Children with ADHD (MTA). The initial design and planning phase of the MTA study occurred during the latter portion of 1992 thru the end of 1993, where the divergent study designs and goals of the various investigators were blended into a cohesive, coherent, and scientifically rigorous final design. The 24-month MTA Study (14 months of treatment, followed by a 10-month follow-up assessment) of 579 children with ADHD was conducted at seven treatment sites over the course of the next four years. Participants were assessed before, during, and at the end of 14 months of treatment, and 10 months later. Treatment was received depending on to which one of four groups participants were randomized (medication alone, behavioral treatment alone, medication plus behavioral treatment, community treatment as usual). This five-year period was supported by NIMH cooperative agreement grants to the clinical sites. At the 24-month point, a Local Normative Control Group of grade- and school-matched non-patients was added as a comparator group. With the support of a subsequent competing supplement to each site, 36-month follow-up assessments were completed. The original MTA aims addressed the following questions: What are the differences in effectiveness for medication management versus intensive behavioral treatments? What are the additive/synergistic effects of combined medication and psychosocial treatment compared to either treatment delivered alone? What is the relative effectiveness of systematic, well-delivered treatments vs. ¿standard¿ treatments typically received in the community? Additional questions the MTA investigators sought to address included the prediction and mediation of treatment-related gains from individual (e.g., co-morbidity), familial (e.g., child-rearing practices), and/or social (e.g., SES) variables. This current contract supports assessment and data collection for follow-up year 12 of the MTA study, at the seven original sites. Each site is supported by an individual contract to that site.

该合同的目的是通过对参加ADHD儿童（MTA）的多模式治疗研究的受试者进行系统的随访，研究注意力缺陷多动障碍（ADHD）儿童的不同治疗方式的长期影响。 MTA研究的最初设计和计划阶段发生在1992年底到1993年底，在1993年底，各种研究人员的不同研究设计和目标被融合为具有凝聚力，连贯和科学严格的最终设计。在接下来的四年中，在七个治疗部位进行了24个月的MTA研究（14个月的治疗，然后进行10个月的随访评估）。参与者在治疗的14个月后以及10个月后进行了评估。接受治疗，具体取决于四组参与者的一组是随机分组的（单独用药，仅行为治疗，药物加上行为治疗，像往常一样）。 NIMH合作协议向临床场所提供了支持。在24个月的时间里，添加了一个当地的年级和学校匹配的非患者的局部规范对照组，作为比较组。在随后对每个站点的竞争补充剂的支持下，完成了36个月的随访评估。 最初的MTA目的解决了以下问题：药物管理与强化行为治疗的有效性有何不同？与单独提供的任何一种治疗相比，相比，联合药物和社会心理治疗的添加剂/协同作用是什么？与社区中通常接受的系统性良好治疗与标准治疗的相对有效性是什么？ MTA调查人员认为解决的其他问题包括对治疗相关的收益的预测和调解，例如，家庭（例如，家族），家庭（例如，育儿实践）和/或社交（例如SES）变量。 该当前合同支持MTA研究第12年的评估和数据收集，在七个原始地点。每个站点都由该站点的个人合同支持。