AUSTRALIAN CHILDREN OF ALCOHOLIC FEMALE TWINS

澳大利亚酗酒女性双胞胎的孩子

• 批准号: 7072847
• 负责人: WENDY S SLUTSKE
• 金额: $ 24万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7072847
• 关键词: Australia; adolescence (12-20); alcoholism /alcohol abuse; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; conduct disorder; early experience; family genetics; gene environment interaction; genetic susceptibility; human subject; interview; longitudinal human study; maternal behavior; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); mother child interaction; oppositional defiant disorder; twin /multiplet; young adult human (21-34)

The goal of this competing continuation request is to examine the role of genetic and family environmental influences, and their interaction, in the development and course of alcohol use disorders (AUD). This is to be achieved using a research strategy that incorporates 3 novel features: (a) use of the infrequently implemented yet powerful children of twins (COT) design involving twins who are concordant or discordant for-AUD as well as control pairs; (b) assessment of children of alcoholic mothers; (c) use of a prospective design which allows for the description of offspring development from preadolescence through the late twenties. The COT design is particularly well suited for studying environmental variables associated with maternal alcoholism in that statistical controls for genetic influences are embedded within the design, providing the opportunity to isolate environmental variables that are etiologically relevant to the development of alcohol problems. It is also well suited for detecting the contribution of genetic transmission to the association between AUDs in parents, and other disorders in offspring (e.g. Attention Deficit Hyperactivity Disorder, ADHD), as well as potential genotype x environment interaction effects. The assessment of twin mothers will fill an important research need in the field and will allow for comparisons with our MARC-affiliated studies involving the same design but based on twin fathers. Finally, our longitudinal, prospective design will allow us to make much stronger statements concerning the development of AUD than would be possible using only retrospective data from a cross-sectional study. During the renewal period, we will continue to expand our recruitment efforts, broadening our eligibility criteria to include mothers with offspring as young as 7 years. In so doing we will be able to confirm or disconfirm our emerging data based on retrospective reports of twin mothers about their adolescent and young adult offspring on disorders with early childhood onset (ADHD, Oppositional Defiant Disorder [ODD], conduct disorder [CD]). We will continue follow-up assessments by maternal interview (offspring aged 9-18) and offspring interview (aged 11-30). By the end of the renewal period, samples will be sufficiently large so that complex cross-sectional and longitudinal analyses will be firmly based.

这一竞争性延续请求的目标是检查遗传和家庭的作用 环境影响及其相互作用在酒精使用障碍（AUD）的发展和过程中。这是通过采用包含 3 个新颖特征的研究策略来实现的：(a) 使用很少实施但功能强大的双胞胎子女 (COT) 设计，涉及 AUD 一致或不一致的双胞胎以及对照对； (b) 对酗酒母亲的孩子进行评估； (c) 使用前瞻性设计，可以描述从青春期前到二十岁后期的后代发育。 COT 设计特别适合研究与孕产妇酗酒相关的环境变量，因为设计中嵌入了遗传影响的统计控制，从而提供了隔离与酒精问题发展病因相关的环境变量的机会。它还非常适合检测遗传传播对父母 AUD 与后代其他疾病（例如注意力缺陷多动障碍，ADHD）之间关联的贡献，以及潜在的基因型 x 环境相互作用效应。对双胞胎母亲的评估将满足该领域的重要研究需求，并将允许与我们涉及相同设计但基于双胞胎父亲的 MARC 附属研究进行比较。最后，我们的纵向前瞻性设计将使我们能够 与仅使用横断面研究的回顾性数据相比，可以对澳元的发展做出更强有力的陈述。在更新期间，我们将继续扩大招募力度，扩大资格标准，将子女年仅 7 岁的母亲纳入其中。这样，我们将能够根据双胞胎母亲关于其青春期和年轻成年后代的儿童早期发病疾病（ADHD、对立违抗性障碍 [ODD]、品行障碍 [CD]）的回顾性报告来确认或否定我们的新数据。 。我们将继续通过母亲访谈（9-18岁后代）和后代访谈（11-30岁）进行后续评估。到续订结束时 在此期间，样本将足够大，以便复杂的横截面和纵向分析将有坚实的基础。