PROTEIN METABOLISM IN OBESITY AND NIDDM

肥胖和 NIDDM 中的蛋白质代谢

• 批准号: 6114013
• 负责人: DAVID J BRILLON
• 金额: $ 7.95万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114013
• 关键词: clinical research; computer data analysis; human data; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; obesity; protein metabolism; proteolysis

Proteolysis is increased in obese diabetic (NIDDM) and nondiabetic individuals compared to nonobese nondiabetics. This study's aim is to determine whether NIDDM is associated with increased proteolysis independent of obesity by evaluating protein kinetics in nonobese diabetic individuals. The investigators will also determine whether NIDDM and obesity are associated with insulin resistance with respect to protein metabolism. Progress report and summary of findings: No patients admitted during this period. Preliminary data showed increased whole body proteolysis in type 2 Diabetes Mellitus, but there were not sufficient subjects for the finding to achieve significance.

与非肥胖非糖尿病患者相比，肥胖糖尿病患者 (NIDDM) 和非糖尿病患者的蛋白水解作用增加。 本研究的目的是通过评估非肥胖糖尿病个体的蛋白质动力学，确定 NIDDM 是否与独立于肥胖的蛋白质水解增加相关。 研究人员还将确定 NIDDM 和肥胖是否与蛋白质代谢方面的胰岛素抵抗有关。进展报告和调查结果摘要： 在此期间没有患者入院。 初步数据显示 2 型糖尿病患者全身蛋白水解增加，但没有足够的受试者使这一发现具有显着性。