EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

糖尿病干预和并发症的流行病学 (EDIC)

• 批准号: 7378371
• 负责人: DAVID J BRILLON
• 金额: $ 2.84万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378371
• 关键词: EPIDEMIOLOGY; DIABETES; INTERVENTIONS; COMPLICATIONS; EDIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In January 2006, the DCCT/EDIC enters the 10-year extension of the follow-up of the cohort. The Core protocol is the same as the basic protocol followed for the first 12 years of EDIC. The Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study have established the short-term and longer-term impact of intensive diabetes therapy on retinopathy, nephropathy, neuropathy, and cardiovascular disease (CVD). In addition, they have defined the roles of hyperglycemia and other risk factors on the development and progression of complications. The previous results of DCCT/EDIC have been seminal in developing the modern-day therapy of Type 1 diabetes that has been adopted worldwide. The DCCT/EDIC cohort has been followed with consistent, validated methods for a mean of 16 (13-20) years with 94% retention and represents the most carefully studied group of Type 1 diabetic patients in history. The current protocol describes further follow-up of the DCCT/EDIC cohort with the goals of: determining the very long-term effects of the original interventions on advanced complications; exploring the longevity of the imprinting ("metabolic memory") phenomenon; delineating the modern-day clinical course of diabetic complications including the interactions among complications and co-occurrence of complications; examining the long (er)-term effects of intensive vs. conventional therapy on cardiovascular events; exploring the pathophysiologic mechanisms that underlie the development and progression of microvascular, neurologic, and cardiovascular complications; and defining the long-term quality of life and economic impacts of intensive therapy.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。 2006年1月，DCCT/EDIC进入该队列的10年延期随访。核心协议与 EDIC 前 12 年遵循的基本协议相同。糖尿病控制和并发症试验 (DCCT) 以及糖尿病干预和并发症流行病学 (EDIC) 后续研究已经确定了强化糖尿病治疗对视网膜病变、肾病、神经病变和心血管疾病的短期和长期影响。化学气相沉积）。此外，他们还定义了高血糖和其他危险因素对并发症发生和进展的作用。 DCCT/EDIC 之前的结果对于开发已在全球范围内采用的现代 1 型糖尿病疗法具有重要意义。 DCCT/EDIC 队列采用一致、经过验证的方法进行平均 16 (13-20) 年的跟踪，保留率为 94%，代表了历史上研究最仔细的 1 型糖尿病患者组。目前的方案描述了 DCCT/EDIC 队列的进一步随访，其目标是： 确定原始干预措施对晚期并发症的长期影响；探索印记（“代谢记忆”）现象的寿命；描述糖尿病并发症的现代临床过程，包括并发症之间的相互作用和并发症的同时发生；检查强化治疗与常规治疗对心血管事件的长期（呃）影响；探索微血管、神经和心血管并发症发生和进展的病理生理机制；并确定强化治疗的长期生活质量和经济影响。