VISUAL SYSTEM ORGANIZATION AND DEVELOPMENT

视觉系统的组织和开发

• 批准号: 6518278
• 负责人: Vivien A Casagrande
• 金额: $ 35.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-02-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518278
• 关键词: Primates; brain electrical activity; brain imaging /visualization /scanning; developmental neurobiology; electron microscopy; electrophysiology; experimental brain lesion; eye movements; histology; lateral geniculate body; neural information processing; neuroanatomy; neuronal transport; single cell analysis; visual cortex; visual deprivation; visual pathways; visual perception

DESCRIPTION: In the PI's working model of visual information processing, three segregated parallel pathways (magnocellular (M), parvicellular (P), and koniocellular (K)) from the lateral geniculate nucleus (LGN) to primary visual cortex (V1) are utilized by the laminar and compartmental (i.e. cytochrome oxidase (CO) blob and interblob) circuitry of V1 to synthesize new output pathways appropriate for the next steps of analysis. Within this scheme, separate output layers and compartments of V1 have distinct modes for integrating signals from all three input pathways and generating output signals that support extrastriate areas, specialized not for specific attributes, but for more complex visual analysis. In light of this model, the project's broad aims are to test the significance of these pathways, define how input pathways engage the circuitry of V1 layers and compartments, and discern the strategies utilized by the output pathways to support V1 target areas. This proposal focuses on the K and the M input pathways and on output pathways to visual area 2 (V2), the dorsal medial visual area (DM), and the middle temporal visual area (MT). The specific aims are designed to test hypotheses generated by our working model. In Aim I, the PI will examine the K pathway and how this and other pathways are integrated within the CO-blobs of V1. In Aim II, she will determine the relationship of LGN K (or M) cell activity to eye movements or to behavioral relevance. In Aim III she will define the organization of V1 output pathways from CO-blob columns. The results of this proposed studies will contribute important new information to the fundamental understanding of how the brain processes visual information and of brain architecture in general.

描述：在PI的视觉信息处理工作模型中， 三个分离的平行通路（大细胞（M）、小细胞（P）、 和koniocellular (K))从外侧膝状核(LGN)到初级 视觉皮层 (V1) 由层状皮层和区室皮层（即： V1 的细胞色素氧化酶 (CO) 斑点和间斑点）电路进行合成 适用于下一步分析的新输出途径。 在此范围内 方案中，V1 的单独输出层和隔室具有不同的模式 用于集成来自所有三个输入路径的信号并生成输出 支持外域区域的信号，专门用于而非特定的 属性，但用于更复杂的视觉分析。 根据该模型，该项目的总体目标是测试 这些途径的重要性，定义输入途径如何参与 V1 层和隔室的电路，并识别所使用的策略 通过输出路径来支持 V1 目标区域。 该提案的重点是 K 和 M 输入通路以及视觉区域 2 (V2) 的输出通路， 背内侧视觉区 (DM) 和中颞视觉区 （公吨）。 具体目标旨在检验我们提出的假设 工作模型。 在目标 I 中，PI 将检查 K 通路以及该通路和其他通路如何 被集成到 V1 的 CO-blob 中。 在《目标 II》中，她将确定 LGN K（或 M）细胞活性与眼球运动或行为的关系 关联。 在目标 III 中，她将定义 V1 输出的组织 来自 CO-blob 柱的路径。 这项拟议研究的结果将 为基本理解如何提供重要的新信息 大脑一般处理视觉信息和大脑结构。