EFFECTS OF ABUSED DRUGS ON PERCEPTION: AN ANIMAL MODEL

滥用药物对感知的影响：动物模型

• 批准号: 6515654
• 负责人: ROBERT D HIENZ
• 金额: $ 28.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515654
• 关键词: animal communication behavior; baboons; disease /disorder model; drug abuse; model design /development; perception; psychopharmacology; sound perception

The proposed research will investigate a new animal model of the effects of abused drugs upon perceptual function. The model focuses upon the auditory perception of biologically relevant, species-specific communication signals in primates and will provide for experimental studies on perceptual processes within the broader context of the social communication systems of the savanna baboon, Papio cynocephalus. The proposed research will 1) extend the analysis of the effects of drugs of abuse on perceptual processes to the perception of species-specific communication signals in baboons, and 2) examine the effects of major drugs of abuse such as stimulants and anxiolytics on the perception of communication signals associated with differing motivational and social contexts (e.g., affiliative, aggressive, submissive). The use of well-established psychophysical procedures will provide for precise, quantitative assessments of drug effects on perceptual function, and digitally generated exemplars of actual baboon calls will be employed to provide for precise control of relevant acoustic features. One set of experiments will compare the similarities of the previously- demonstrated effects of drugs of abuse on perception of speech sounds with the effects of drugs of abuse on the perception of species-specific vocalizations. A second set of experiments will examine the relationship between a drug's perceptual effects and the type of social communication signal being discriminated. A third set of experiments will examine the relationship between a drug's perceptual effects and the social rank of the sender and receiver of the signal. This research will provide fundamental data on the effects of drugs of abuse on perceptual function in nonhuman primates, and on the perception of communication signals of motivational and/or social significance. This research will advance our understanding of factors which contribute to the abuse liability of widely abused drugs, and will yield information directly relevant to the clinical implications of the perceptual effects associated with the use and abuse of drugs.

拟议的研究将研究一种新的动物模型，以了解滥用药物对感知功能的影响。 该模型侧重于灵长类动物中对生物学相关的，特定于物种的交流信号的听觉感知，并将在Savanna Baboon，Papio Cynoc​​ephalus的社会交流系统的广泛背景下提供有关感知过程的实验研究。 拟议的研究将1）将滥用药物对感知过程的影响的分析扩展到对狒狒中物种特异性交流信号的感知，2）检查主要滥用药物的影响，例如兴奋剂和抗焦虑药对与动机和社会环境不同的沟通信号的感知（例如，促进性和社会环境的差异）。 使用良好的心理物理程序将提供对药物对感知功能的影响的精确定量评估，并且将采用数字化的实际狒狒调用典范来提供对相关声学特征的精确控制。 一组实验将比较先前证明的滥用药物对语音感知的影响与滥用药物对物种特异性发声的影响的相似之处。 第二组实验将研究药物的感知影响与被歧视的社交交流信号类型之间的关系。 第三组实验将检查药物的感知效应与信号的接收器的社会等级之间的关系。 这项研究将提供有关滥用药物对非人类灵长类动物感知功能的影响的基本数据，以及对动机和/或社会意义的传播信号的感知。 这项研究将提高我们对有助于广泛滥用药物的滥用责任的因素的理解，并将产生与与使用和滥用药物有关的感知作用的临床意义直接相关的信息。