DRUG DEPENDENCE AND HIV/AIDS: A NEW BIOBEHAVIORAL MODEL

药物依赖和艾滋病毒/艾滋病：新的生物行为模型

• 批准号: 6146766
• 负责人: ROBERT D HIENZ
• 金额: $ 14.52万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6146766
• 关键词: HIV infections; Macaca nemestrina; behavioral /social science research tag; body temperature; disease /disorder model; drug addiction; drug withdrawal; immunopharmacology; morphine; pathologic process; psychological models; simian immunodeficiency virus; substance abuse related behavior; telemetry

The proposed research will explore the development of a laboratory animal model for the experimental analysis of both chronic, long-term drug use and HIV/AIDS. The nonhuman primate model to be explored will combine current oral drug dosing techniques with a well-defined simian immunodeficiency virus (SIV-macaque model of HIV/AIDS to investigate the viral, behavioral, and CNS consequences associated with chronic exposure to drugs of abuse, SIV viruses, and their combination. First, oral self-dosing techniques will be used to establish chronic morphine dependence in macaque monkeys, with morphine dependence being assessed and monitored via the recording of continuous telemetric data on body temperature and general activity, and via behavioral observations of drug dependence. Second, the effects of chronic morphine self-dosing on immune function will be concurrently evaluated by assessing immune function during the development of dependence, during chronic morphine dependence, and during periods of withdrawal (short-term abstinence and precipitate withdrawal). Third, the effects of morphine dependence on the disease process will be assessed by comparing all measures (body temperature, general activity, immune system function) in groups of morphine-dependent and drug-free animals throughout the course of SIV disease progression. The development of a nonhuman primate model for the investigation of the effects of both chronic drug administration and SIV disease will be an important tool in advancing the scientific understanding of the relationship between drug use and HIV/AIDS, and their consequences on cognitive/behavioral processes.

拟议的研究将探索实验室的发展 用于对慢性长期药物使用的实验分析的动物模型 和艾滋病毒/艾滋病。要探索的非人类灵长类动物模型将结合电流 口服药物给药技术具有明确的猿猴免疫缺陷病毒 （HIV/AIDS的SIV-MACAQUE模型研究病毒，行为和CNS 与长期暴露于滥用药物，SIV病毒， 和它们的组合。首先，口服自我剂量技术将用于 用吗啡在猕猴中建立慢性吗啡依赖性 通过记录连续评估和监测依赖性 关于体温和一般活动的遥测数据，以及通过行为 对药物依赖性的观察。其次，慢性吗啡的影响 通过评估，将同时评估免疫功能的自我剂量 依赖期间的依赖期间的免疫功能在慢性吗啡期间 依赖性，以及在退出期间（短期禁欲和 沉淀提取）。第三，吗啡依赖对 疾病过程将通过比较所有措施（体温， 一般活动，免疫系统功能）在吗啡依赖性和 在整个SIV疾病进展过程中，无毒品动物。这 开发非人类灵长类动物模型，以研究 慢性药物管理和SIV疾病都将成为重要的工具 促进对吸毒与使用与毒品之间关系的科学理解 艾滋病毒/艾滋病及其对认知/行为过程的后果。