Epidemiology of Ovarian Age

卵巢年龄的流行病学

• 批准号: 6474778
• 负责人: Jennie Katherine Kline
• 金额: $ 28.87万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6474778
• 关键词: age at pregnancy; aging; alcoholic beverage consumption; body physical characteristic; body weight; caffeine; clinical research; disease /disorder proneness /risk; egg /ovum; epidemiology; estradiol; female; follicle stimulating hormone; graafian follicles; human data; inhibin; lifestyle; menopause; ovary; reproductive development; smoking; spontaneous abortion; tobacco abuse; trisomy

DESCRIPTION (provided by applicant): The goal of this study is to identify factors that influence ovarian age. We define "ovarian age" as the size of oocyte pool. Ovarian follicle (oocyte) counts are highest before birth and decrease as women age; similarly, the number of follicles that develop during each menstrual cycle decreases as women age. At any particular chronologic age, women vary in both the size of their oocyte pools and the number of antral (developing) follicles. These variations may reflect differences in the size of the pool at its formation or in rates of oocyte atresia. Increasing numbers of women are deferring childbearing to the later years. Since ovarian aging is accompanied by conception delay and an increased risk of infertility and trisomic conception, the identification of risk factors for accelerated ovarian aging would have significant implications for reproductive research and primary prevention. The proposed study draws on data from two already completed studies to identify risk factors for ovarian age. In the first study, ovarian age is measured by age at onset of the menopausal transition and at menopause in 494 women. In the second study. ovarian age is measured shortly after an index pregnancy by counts of ovarian antral follicles and three hormonal indicators of ovarian age-follicle stimulating hormone, inhibin B and estradiol-in 173 women. Both studies include extensive data on maternal characteristics and exposures that might influence ovarian aging. They thus provide an excellent and unique opportunity to (i) identify determinants of ovarian age in fertile women during natural cycles and (ii) examine whether determinants of ovarian age during the reproductive years differ from determinants during the menopausal transition. The specific aims are: 1. To examine whether maternal characteristics (e.g., body mass index) or exposures (e.g., smoking) are associated with ovarian age measured by (i) antral follicle counts, (ii) selected hormonal indicators, (iii) age at onset of the menopausal transition, and (iv) age at menopause. 2. To conduct exploratory studies, using data from the Oocyte study, to assess whether or not skewed X-inactivation is associated with advanced ovarian age.

描述（由申请人提供）：本研究的目的是确定 影响卵巢时代的因素。我们将“卵巢时代”定义为 卵母细胞池。卵巢卵泡（卵母细胞）出生前最高 随着妇女的年龄而减少；同样，在 随着女性的年龄，每个月经周期都会降低。在任何特定的年代年龄， 女性的卵母细胞大小和粪便的数量各不相同 （发展）卵泡。这些变化可能反映了大小的差异 池以其形成或卵母细胞闭锁的速率。增加数量 妇女将生育时间推迟到后期。由于卵巢衰老是 伴随着受孕的延迟以及不育的风险增加 三化概念，鉴定加速卵巢的危险因素 衰老将对生殖研究和主要研究产生重大影响 预防。 拟议的研究借鉴了来自两项已完成研究的数据，以识别 卵巢年龄的危险因素。在第一项研究中，卵巢年龄由 在绝经期和494名妇女的更年期时期的年龄。在 第二项研究。卵巢年龄在指数怀孕后不久测量 卵巢肛门卵泡的数量和卵巢的三个荷尔蒙指标 刺激激素，抑制素B和雌二醇173名女性的年龄囊泡。两个都 研究包括有关母体特征和暴露的大量数据 可能会影响卵巢衰老。因此，他们提供了出色而独特的 有机会（i）确定肥沃妇女卵巢年龄的决定因素 自然周期和（ii）检查卵巢年龄的决定因素是否在 生殖年与绝经期间的决定因素不同。 具体目的是： 1。检查母体特征（例如体重指数）还是 暴露（例如吸烟）与（i）测得的卵巢年龄有关 鼻卵泡计数，（ii）选定的激素指标，（iii）发作时的年龄 更年期过渡，以及（iv）更年期的年龄。 2。使用卵母细胞研究的数据进行探索性研究，以评估 是否偏斜X灭活与晚期卵巢时代有关。