RENAL TRAINING GRANT IN CLINICAL INVESTIGATION

临床研究中的肾脏训练补助金

• 批准号: 6523932
• 负责人: MARK E. ROSENBERG
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6523932
• 关键词: RENAL; TRAINING; GRANT; CLINICAL; INVESTIGATION

DESCRIPTION (adapted from the application) The proposed training program will be provided to trainees who have completed a year of clinical nephrology training and who will enter the Clinical Research Masters Program at the University of Minnesota. Each trainee will identify a research mentor prior to entering the program. Research will be initiated concurrently with course work in the Masters program. This program includes 38 credit hours of study in epidemiology, biostatistics, clinical trials, literature review and grant writing. It is a new course of study directed by Stephen Glasser who will also sit on the Selection and Steering Committees for the proposed training grant. The research project required for this degree will be combined with an additional year of research with a mentor of the Nephrology training faculty; all projects will be approved by Glasser and the Masters Program Executive Committee. Drs. Rosenberg and Glasser will coordinate communication between the faculty of the Masters and Nephrology Clinical Research programs as is related to these research projects. Trainees will be evaluated on a quarterly basis by the mentor and annually on the basis of scientific presentations and publications by the advisory committee and Steering Committee. In addition to the formal course work and individual research project, trainees will attend conferences in the Renal Division and the Department of Medicine and will participate in a continuity clinic in Nephrology. Administrative structure of the program will include a Steering Committee with representation from the clinical Masters Program, Hennepin County, and the Divisions of Nephrology and Pediatric Nephrology and from the Berman Center for Outcomes and Clinical Research. The Selection Committee will include Division Directors at each of the clinical sites and the Vice Chair of Medicine. Individual Advisory Committees will be provided for each trainee and will be comprised of the advisor and four faculty members. The committee will meet annually and provide review of progress, guidance in use of Core facilities, and advice in seeking continued research funding at the end of the training period. Six research units are described including Transplantation, headed by Dr. Kasiske; ESRD, Dr. Colllins; Progression of Renal Disease, Dr. Hostetter; Diabetic Nephropathy, Dr. Mauer; Hypertension, Dr. Grimm; and Pediatric Nephrology, Dr. Kashtan. Core Resources include: the Clinical Outcomes Research Center (CORC), a joint venture of the Medical School and the School of Public Health, the Berman Center for Outcomes and Clinical Research, Total Renal Research, the NIH funded General Clinical Research Center (GCRC), the Academic Health Center Research Service Organization, Nephrology Analytical Services, and the Coordinating Center for Biometric Research. The CORC provides an epidemiological approach with an emphasis on outcomes of survival and satisfaction, physical and social functioning and quality of life. Support is also provided for prospective studies of therapies with systematic collection of follow-up data. The Berman Center is the research arm of the Division of Clinical Epidemiology at Hennepin County and has been a site for clinical trials since 1965. Total Renal Research is a clinical research facility with emphasis on Phase I through IV trials in patients with hypertension, renal insufficiency, on dialysis, or with renal transplants. The GCRC has a long history of success with NIH funding and includes inpatient and outpatient facilities; over 60 protocols are active. The Research Services Organization provides support to researchers in research protocols, management and performance and interface with industry. Involvement in over 100 proposals has led to initiation of 44 trials in the last two years. Nephrology Analytical Services receives data from HCFA and performs outcomes research regarding ESRD patients. The coordinating Center for Biometric Research is a subunit of the Division of Biostatistics of the School of Public Health. This center will provide access to large databases including several relating to hypertension as well as the USRDS data.

描述（根据应用程序改编） 拟议的培训计划将提供给已经完成的学员 临床肾脏病学年培训，谁将进入临床研究 明尼苏达大学的硕士课程。每个学员都会确定 进入计划之前的研究导师。研究将开始 同时与硕士课程中的课程工作。该程序包括38 流行病学，生物统计学，临床试验的学分研究时间， 文献综述和赠款写作。这是由 斯蒂芬·格拉瑟（Stephen Glasser）也将参加选择和指导委员会 拟议的培训补助金。该学位所需的研究项目将 与肾脏病的导师一起进行额外的研究一年 培训教师；所有项目将获得格拉瑟和大师的批准 计划执行委员会。博士。罗森伯格和格拉瑟将协调 大师师和肾脏学临床的沟通 与这些研究项目有关的研究计划。学员会 由导师进行季度评估，并根据 咨询委员会的科学演讲和出版物和出版物 指导委员会。除了正式课程和个人 研究项目，学员将参加肾部门的会议 医学系将参加连续性诊所 肾脏科。 该计划的行政结构将包括一个指导委员会 Hennepin县临床硕士计划的代表和 肾脏科和小儿肾脏科，以及伯曼中心 结果和临床研究。选拔委员会将包括部门 每个临床部位的董事和医学副主席。 每个学员将提供个人咨询委员会，将是 由顾问和四名教职员工组成。委员会将开会 每年对进度，使用核心设施的指导进行审查， 以及在培训结束时寻求继续研究资金的建议 时期。 描述了六个研究单元，包括由博士领导的移植。 kasiske; ESRD，Colllins博士；肾脏疾病的进展，Hostetter博士； 糖尿病性肾病，毛尔博士；高血压，格林博士；和小儿 肾脏科，Kashtan博士。核心资源包括：临床结果研究 中心（CORC），医学院和公立学校的合资企业 健康，伯曼成果与临床研究中心，总肾脏 研究，NIH资助了一般临床研究中心（GCRC），学术 肾脏分析服务卫生中心研究服务组织， 以及生物特征研究协调中心。 Corc提供了 流行病学方法着重于生存和 满意度，身体和社会功能以及生活质量。支持是 还为系统收集的疗法提供了前瞻性研究 后续数据。伯曼中心是部门的研究部门 Hennepin县的临床流行病学，一直是临床的现场 自1965年以来的试验。全肾脏研究是一家临床研究机构 强调高血压患者的静脉试验IV期试验 不足，透析或肾脏移植。 GCRC有很长的 NIH资金成功的历史，包括住院和门诊病人 设施;超过60个协议活动。研究服务组织 为研究协议，管理和 与行业的绩效和界面。参与100多个建议 在过去的两年中，导致了44次试验。肾脏分析 服务从HCFA接收数据，并进行有关ESRD的结果研究 患者。生物识别研究协调中心是 公共卫生学院生物统计学司。这个中心会 提供对大型数据库的访问，包括与高血压有关的几个 以及USRDS数据。