IV COCAINE ABUSE TREATMENT: A LABORATORY MODEL

静脉注射可卡因滥用治疗：实验室模型

• 批准号: 6544467
• 负责人: Richard W Foltin
• 金额: $ 56.76万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6544467
• 关键词: anticonvulsants; attention deficit disorder; behavior test; behavioral /social science research tag; clinical research; cocaine; comorbidity; craving; disease /disorder model; drug /alcohol abstinence; drug addiction; drug addiction antagonist; drug administration rate /duration; drug withdrawal; human subject; interview; major depression; pharmacokinetics; psychological tests; psychometrics; psychopharmacology; questionnaires; self medication; substance abuse related behavior; venlafaxine

DESCRIPTION (provided by applicant): This protocol continues implementation of a laboratory model to evaluate medications potentially useful in the treatment of cocaine abuse, investigating problems relevant to understanding and reducing uncontrolled cocaine use. Psychiatric comorbidities are pervasive in the cocaine-dependent population, and are significant in the population seen in community treatment centers. However, these comorbidities are rarely addressed in either clinical trials or laboratory settings. While it has been hypothesized that treatment for cocaine dependence could be improved by targeting cocaine users with specific psychiatric comorbidities, this has not been systematically evaluated. We will examine the relationship between psychiatric comorbidity and potential medications for cocaine dependence using two approaches. First, we will compare the subjective and reinforcing effects of cocaine under controlled laboratory conditions, in groups of abstinent cocaine abusers with Major Depressive Disorders (MDD), Attention Deficit/Hyperactivity Disorder (ADHD) or no psychiatric comorbidity. If cocaine use in individuals with comorbid disorders is related to their comorbid. disorder, then the behavioral effects of cocaine should vary across the groups being studied. Second, we will compare responses to cocaine under three separate conditions: maintenance on 1) gabapentin, 2) venlafaxine, and 3) the combination of the two medications. The laboratory, setting of the current proposal offers a unique opportunity to test the hypothesis that individuals with comorbid MDD or ADHD respond differently to cocaine than those without a comorbid psychiatric disorder, and that treating the MDD or ADHD alone will not sufficiently reduce the response to cocaine. Treating the comorbid disorder or decreasing the behavioral effects of cocaine will be necessary but not sufficient pharmacotherapy for individuals with comorbid disorders. A combination of the gabapentin for cocaine and venlafaxine for depressive symptoms will have a synergistic effect in these individuals. The laboratory is an ideal setting in which to carry out this research, allowing us to carefully monitor participants and collect maximal data with the fewest number of participants. The proposed research offers a unique opportunity to evaluate medications in cocaine-dependent individuals with MDD, ADHD or no comorbid disorder, and will provide important information about differential responses of these groups to cocaine and to gabapentin and venlafaxine, alone and in combination.

描述（由申请人提供）：该方案继续实施实验室模型，以评估可能用于治疗可卡因滥用的药物，调查与理解和减少不受控制的可卡因使用相关的问题。精神合并症在可卡因依赖人群中普遍存在，并且在社区治疗中心的人群中尤为严重。然而，这些合并症很少在临床试验或实验室环境中得到解决。虽然有人假设可以通过针对患有特定精神合并症的可卡因使用者来改善可卡因依赖的治疗，但这尚未得到系统评估。我们将使用两种方法检查精神合并症与可卡因依赖的潜在药物之间的关系。首先，我们将在受控实验室条件下，在患有重度抑郁症 (MDD)、注意力缺陷/多动症 (ADHD) 或无精神合并症的戒断可卡因滥用者群体中，比较可卡因的主观效果和强化效果。患有合并症的个体使用可卡因是否与其合并症有关。障碍，那么可卡因的行为影响应该因所研究的群体而异。其次，我们将比较三种不同条件下对可卡因的反应：维持 1) 加巴喷丁、2) 文拉法辛和 3) 两种药物的组合。当前提案的实验室设置提供了一个独特的机会来检验以下假设：患有共病 MDD 或 ADHD 的个体对可卡因的反应与没有共病精神疾病的人不同，并且单独治疗 MDD 或 ADHD 并不能充分降低对可卡因的反应。可卡因。对于患有合并症的个体来说，治疗合并症或减少可卡因的行为影响是必要的，但药物治疗还不够。加巴喷丁治疗可卡因和文拉法辛治疗抑郁症状的组合将对这些个体产生协同作用。实验室是开展这项研究的理想环境，使我们能够仔细监测参与者并以最少的参与者收集最大的数据。拟议的研究提供了一个独特的机会来评估患有MDD、ADHD或无合并症的可卡因依赖个体的药物治疗，并将提供有关这些群体对可卡因、加巴喷丁和文拉法辛单独或联合用药的差异反应的重要信息。