Small Molecule X-Ray Diffraction Instrumentation

小分子 X 射线衍射仪器

• 批准号: 6440796
• 负责人: ANDREW D MESECAR
• 金额: $ 27.38万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6440796
• 关键词: X ray crystallography; biomedical equipment purchase; copper; molybdenum

A state-of-the-art CCD (charge-coupled-device) area detector with sealed-tube x-ray generator and low-temperature cooling device will be purchased and used too collect x-ray diffraction data from single crystals with Mo and Cu radiation. This will be will be used to establish a multi- user, small molecule, single-crystal, x-ray diffraction facility in the College of Pharmacy at the University of Illinois at Chicago (UIC). This facility will principally support research in at least 9 major laboratories including two NIH program grants and one NIH center. Approximately 80% of the instrument will be utilized by NIH-funded researchers, and the remaining time will be used by other researchers on the UIC campus and the Chicago area. In addition, the instrument hardware, software, and computing resources will be used to augment courses in Medicinal Chemistry, Pharmacognosy, Chemistry and Pharmaceutical Biotechnology. This instrument will replace the slow, aging, and somewhat unreliable CAD4 diffractometer that is housed on the eat campus near Chemistry. To date, most of the structures solved for UIC faculty research projects have occurred through off-campus collaborations or through off-campus data collection, when available. This instrument will be located on the west medical campus immediately adjacent to the UIC/RRC MacroMolecular Diffraction Facility; this increases the accessibility of the instrument for both research and training. Access to the instrument by new users on and off campus will be assured through the administrative oversight of an advisory committee and the Research Resources Center (RRC). The RRC is a centralized campus center and instrumentation facility that has been in operation for over fifty years. The RRC will handle maintenance of the instrumentation in collaboration with the director of the facility and the advisory committee. Dr. Santarsiero has been hired as the director of the new facility. His primary function is to oversee operations and maintenance of this service facility through contact with RRC, the Dean of the College of Pharmacy, the advisory committee and the research faculty. The mechanism of sample submission will be established by the advisory committee and will include hands-on use by graduate students and postdoctoral researchers. As outlined, this facility will substantially benefit several research programs and NIH program grants and centers. The much increased need for such instrumentation reflects the growing importance of structural chemistry and structural biology as a component in research and teaching at the University of Illinois at Chicago, as well as several new initiatives in the areas of structural biology and chemistry at UIC.

将购买带有密封管X射线发生器和低温冷却装置的最先进的CCD（电荷耦合设备）检测器，并从具有MO和CU辐射的单晶体中收集X射线衍射数据。这将用于建立伊利诺伊大学芝加哥大学药学学院（UIC）的药学学院的多用户，小分子，单晶，X射线衍射设施。该设施将主要支持至少9个主要实验室的研究，其中包括两个NIH计划赠款和一个NIH中心。 NIH资助的研究人员将使用大约80％的工具，其余时间将被UIC校园和芝加哥地区的其他研究人员使用。此外，仪器硬件，软件和计算资源将用于增加药物化学，药物，化学和药物生物技术的课程。该仪器将取代在化学附近的EAT校园中安装的缓慢，老化和某种不可靠的CAD4衍射仪。迄今为止，为UIC教师研究项目所解决的大多数结构都是通过校外协作或校外数据收集（如果有）发生的。该仪器将位于附近的西部医疗校园，与UIC/RRC大分子衍射设施相邻；这增加了研究和培训工具的可及性。通过咨询委员会和研究资源中心（RRC）的行政监督，将确保校园内外的新用户访问该工具。 RRC是一个集中式校园中心和仪器设施，已经运营了五十多年。 RRC将与设施和咨询委员会主任合作处理仪器的维护。 Santarsiero博士已被聘为新工厂的主任。他的主要功能是通过与药学学院，咨询委员会和研究学院RRC的联系来监督该服务机构的运营和维护。样本提交的机制将由咨询委员会建立，并将包括研究生和博士后研究人员的动手使用。如概述，该设施将基本上使几项研究计划和NIH计划赠款和中心受益。对这种仪器的需求极大地反映了伊利诺伊大学芝加哥大学研究和教学的结构化学和结构生物学的重要性，以及UIC结构生物学和化学领域的几项新计划。