Research console for 4T imager

4T 成像仪研究控制台

• 批准号: 6889445
• 负责人: JERRY D GLICKSON
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889445
• 关键词: biomedical equipment purchase; electroencephalography; evoked potentials; infrared spectrometry; magnetic resonance imaging

DESCRIPTION (provided by applicant): The University of Pennsylvania seeks to acquire a Varian INOVA console for a GE 4T whole-body MRI scanner. The current GE console on the 4T system is outdated, and there is no user interest or funds for upgrading it to the latest version. The instrument is dedicated 100 percent to research, and it will operate 100 percent of the time with the proposed Varian console. There will be seven major user programs, 15 Principal Investigators, supported by 23 NIH grants ($9,368,824 current year, $40,095,857 funding cycle). The proposed console will facilitate translation to clinical applications of unique pulse sequences developed for studies of small animals on experimental Varian INOVA spectrometers and other instruments both at Penn and at other institutions. Programming pulse sequences on the GE console has been prohibitively difficult and time consuming and has impeded progress on critical projects ultimately directed at detection and treatment of human diseases. Access to clinical instruments is currently saturated and is inadequate to support the user projects. Many of the projects require accessories for simultaneous near infrared imaging, electroencephalography (EEG or ERP) and inmagnet exercise routines that cannot be performed in clinical instruments. Placement of a Varian console on a 4T instrument will greatly facilitate development of clinical spectroscopy and imaging applications relevant to arthritis, cancer, neurological disorders, gene therapy of muscular dystrophy and lysosomal storage diseases, and basic human physiology. For instance, Project I focuses on translation to human subjects of single and multiple quantum Na MRI and 1H MRI of cartilage developed on animal models of arthritis. Project II is directed at prediction and detection of human tumors to chemotherapy and radiation in humans with non- Hodgkin's lymphoma and head and neck cancer and selection of melanoma patients for isolated limb perfusion/ chemotherapy/hyperthermia. Proton MRS/MRI lactate and choline imaging require programming of special pulse sequences, and 31P MRS requires the improved resolution and sensitivity achieved at high field. Project 5 involves the development of simultaneous MRI/MRS and NIR on human subjects for examination of muscle physiology during in-magnet exercise, functional imaging of adolescent brains during cognitive task performance and detection of breast cancer. This project requires access to a dedicated research instrument in order to develop these dual imaging and imaging-exercise capabilities. Muscle 31P MRS studies need 4T for the resolution required to monitor specific muscle fibers, Each of the other four project areas will similarly benefit from access to the 4T equipped with the new console.

描述（由申请人提供）： 宾夕法尼亚大学寻求为GE 4T全身MRI扫描仪购买Varian Inova控制台。 4T系统上的当前GE控制台已过时，并且没有将其升级到最新版本的用户兴趣或资金。该仪器专用于100％进行研究，并将在拟议的Varian控制台上运行100％的时间。将有7个主要用户计划，15名主要调查人员，由23个NIH赠款（$ 9,368,824今年，40,095,857美元的融资周期）支持。拟议的控制台将促进为在宾夕法尼亚州和其他机构的实验Varian INOVA光谱仪和其他仪器上研究的独特脉冲序列的临床应用。 GE控制台上的编程脉冲序列非常困难且耗时，并且阻碍了最终针对人类疾病检测和治疗的关键项目的进展。目前可以使用临床仪器，并且不足以支持用户项目。许多项目都需要配件，以同时进行近红外成像，脑电图（EEG或ERP）和无法在临床仪器中执行的Inmagnet锻炼程序。将Varian控制台放置在4T仪器上，将极大地促进与关节炎，癌症，神经系统疾病，肌肉营养不良症和溶酶体储存疾病的基因治疗有关的临床光谱和成像应用的发展。例如，I项目专注于转化为在关节炎动物模型上开发的单量子和多个量子NA MRI和1H MRI的人类主体。项目II致力于预测和检测非霍奇金淋巴瘤和头颈癌的人类化学疗法和放疗的人类肿瘤，以及用于孤立的肢体灌注/化学疗法/高温治疗的黑色素瘤患者的选择。质子MRS/MRI乳酸和胆碱成像需要特殊脉冲序列的编程，而31p MRS需要在高场上提高分辨率和灵敏度。项目5涉及在魔术内运动期间研究肌肉生理学的同时MRI/MRS和NIR的开发，在认知任务表现过程中对青少年大脑的功能成像以及对乳腺癌的检测的功能成像。该项目需要访问专用的研究工具，以开发这些双重成像和运动能力。肌肉31p MRS研究需要4T来监测特定的肌肉纤维所需的分辨率，其他四个项目区域中的每个项目都将受益于访问配备新控制台的4T。